Production
Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.[1]
2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride:[1]
Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents.
This may refer to:
Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.[1]
2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride:[1]
Chloropyridines are important intermediates to pharmaceuticals and agrochemicals.[1] A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics.