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((short description|Determining if an illness is included in an outbreak investigation))
In [[epidemiology]], a '''clinical case definition''',<ref>((cite journal | author = Keou FX1 Bélec L, Esunge PM, Cancre N, Gresenguet G | date = October 1992 | title = World Health Organization clinical case definition for AIDS in Africa: an analysis of evaluations | journal = East Afr Med J | volume = 69 | issue = 10| pages = 550–3 | pmid = 1335410 ))</ref> a '''clinical definition''', or simply a '''case definition'''<ref>[https://www.atsdr.cdc.gov/csem/csem.html ] Disease Clusters: An Overview
Case Definition from the United States Department of Health and Human Services</ref> lists the clinical criteria by which [[public health]] professionals determine whether a person's illness is included as a ''case'' in an [[outbreak]] investigation—that is, whether a person is considered directly affected by an outbreak. Absent an outbreak, case definitions are used in the surveillance of public health in order to categorize those conditions present in a population (e.g., [[incidence (epidemiology)|incidence]] and [[prevalence]]).

==How are they used==
A case definition defines a case by placing limits on time, person, place, and shared definition with data collection of the phenomenon being studied.<ref>((cite web |url=https://www.cs.columbia.edu/digigov/LEXING/CDCEPI/gloss.html |title=Glossary of Epidemiology Terms |website=www.cs.columbia.edu |url-status=dead |archive-url=https://web.archive.org/web/20030226081750/http://www.cs.columbia.edu/digigov/LEXING/CDCEPI/gloss.html |archive-date=2003-02-26)) </ref><ref>((Cite journal|last1=Collin|first1=Lindsay|last2=Reisner|first2=Sari L.|last3=Tangpricha|first3=Vin|last4=Goodman|first4=Michael|date=2016|title=Prevalence of Transgender Depends on the "Case" Definition: A Systematic Review|url= |journal=The Journal of Sexual Medicine|language=en|volume=13|issue=4|pages=613–626|doi=10.1016/j.jsxm.2016.02.001|pmc=4823815|pmid=27045261))</ref> Time criteria may include all cases of a disease identified from, for example, January 1, 2008 to March 1, 2008. Person criteria may include age, gender, ethnicity, and clinical characteristics such as symptoms (e.g. cough and fever) and the results of clinical tests (e.g. pneumonia on chest X-ray). Place criteria will usually specify a geographical entity such as a town, state, or country, but may be as small as an institution, a school class, or a restaurant meal session. Shared definition of the phenomenon impacts the study methods and ensures terminology is used in a consistent manner.

Case definitions are often used to label individuals as suspect, probable, or confirmed cases. For example, in the investigation of an outbreak of pneumococcal pneumonia in a nursing home the case definition may be specified as:
* '''Suspect Case:''' All residents of Nursing Home A with onset of cough and fever between January 1, 2008 and February 1, 2008.
* '''Probable Case:''' Meet the suspect case definition plus have pneumonia on chest X-ray.
* '''Confirmed Case:''' Meet the probable case definition plus have pneumococcal infection confirmed by blood culture or other isolation of pneumococci from normally sterile site.

By creating a case definition, public health professionals are better equipped to study an outbreak and determine possible causes.

As investigations proceed, a case definition may be expanded or narrowed, a characteristic of the dynamic nature of outbreak investigations. At any given time, the case definition is supposed to be the [[gold standard (test)|gold standard]] to diagnose a given disease. A [[Sensitivity and specificity|sensitive]] case definition, often applied early in an outbreak, will capture all cases, but will include many non-cases. A [[Sensitivity and specificity|specific]] case definition, usually applied after the outbreak is considered more well understood, will exclude most non-cases, but will also exclude some actual cases.<ref>((Cite web|title=Case definitions for outbreak assessment|url=https://wiki.ecdc.europa.eu/fem/Pages/Case%20definitions%20for%20outbreak%20assessment.aspx|access-date=2020-11-08|website=wiki.ecdc.europa.eu))</ref>

==Diagnostic criteria==
((Unreferenced section|date=September 2019))
The term ''diagnostic criteria'' designates a case definition with a specific combination of [[sign (medicine)|signs]], [[symptom]]s, and test results that the [[clinician]] uses to attempt to determine the correct diagnosis.

Some examples of diagnostic criteria are:
* [[Amsterdam criteria]] for [[hereditary nonpolyposis colorectal cancer]]
* [[McDonald criteria]] for [[multiple sclerosis]]
* [[Systemic lupus erythematosus#Diagnostic criteria|ACR criteria for systemic lupus erythematosus]]
* [[Centor criteria]] for [[Streptococcal pharyngitis|strep throat]]

==Clinical definitions==
When diagnostic criteria are universally accepted they can be considered a "clinical definition" because they define the limits of the affected population, determining which patients are inside and outside of the set.((cn|date=May 2023))

A clinical definition should be regarded as a statistical analysis tool, and not a substitute for a pathological definition when this is required.<ref>José Roberto Lambertucci, Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools, Rev. Soc. Bras. Med. Trop. vol. 47 no. 2 Uberaba Mar./Apr. 2014 Epub Apr 11, 2014, ((doi|10.1590/0037-8682-0186-2013))</ref> [[Posthumous diagnosis]] allows to establish the [[sensitivity and specificity]] of the clinical definitions.<ref>((cite journal | author = Saracci R | year = 1991 | title = Is necropsy a valid monitor of clinical diagnosis performance? | journal = BMJ | volume = 303 | issue = 6807| pages = 898–900 | doi = 10.1136/bmj.303.6807.898 | pmid = 1933005 | pmc = 1671185 ))</ref>

==See also==
* [[Public health|Public Health]]
* [[Epidemiology]]
* [[Outbreak]]
* [[Sensitivity and specificity]]
* [[Medical diagnosis#Diagnostic criteria|Diagnostic criteria]]

==References==
((reflist))

[[Category:Epidemiology]]

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