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((Short description|Medical use of gamma rays))
((Refimprove|date=December 2016))
((Use dmy dates|date=June 2022))
((Infobox medical intervention
| name         = Cobalt therapy
| synonym      =Cobalt-60 therapy
| image        = Nci-vol-1819-300 cobalt 60 therapy.jpg
| caption      = 
| alt          = 
| pronounce    = 
| specialty    = oncology
| synonyms     = 
| ICD10        = 
| ICD9         = 
| ICD9unlinked = 
| CPT          = 
| MeshID       = 
| LOINC        = 
| other_codes  = 
| MedlinePlus  = 
| eMedicine    = 
))

'''Cobalt therapy'''  is the medical use of [[gamma ray]]s from the [[radioisotope]] [[cobalt-60]] to treat conditions such as [[cancer]].  Beginning in the 1950s, cobalt-60 was widely used in [[external beam radiotherapy]] (teletherapy) machines, which produced a beam of gamma rays which was directed into the patient's body to kill tumor tissue.  Because these "cobalt machines" were expensive and required specialist support, they were often housed in ''cobalt units''.  Cobalt therapy was a revolutionary advance in radiotherapy in the post-World War II period but is now being replaced by other technologies such as [[linear accelerator]]s.<ref name="auto">https://www.irsn.fr/sites/default/files/documents/professionnels_sante/documentation/syllabus_chapitre_5.pdf</ref>

==History==
((Moresources|section|date=November 2022))
Before the development of medical [[linear accelerator]]s in the 1970s, the only artificial radiation source used for [[teletherapy]] was the [[x-ray tube]].  Researchers found ordinary x-ray tubes, which used voltages of 50-150&nbsp;keV, could treat superficial tumors, but did not have the energy to reach tumors deep in the body. To have the penetrating ability to reach deep-seated tumors without subjecting healthy tissue to dangerous radiation doses required rays with energy around a million electron volts (MeV), called "megavoltage" radiation. To produce a significant amount of MeV x-rays required potentials on the tube of 3-5 million volts (3-5 megavolts), necessitating huge, expensive x-ray machines. By the late 1930s these were being built, but they were available at only a few hospitals.

[[File:Eldorado A.jpeg|thumb|upright=1.3|The first cobalt machine in Italy, installed in [[Borgo Valsugana]] in 1953.]]

[[Radioisotope]]s produced [[gamma ray]]s in the megavolt range, but prior to [[World War II]] virtually the only radioisotope available for radiotherapy was naturally occurring [[radium]] (producing 1-2&nbsp;MeV gamma rays), which was extremely expensive due to its low occurrence in ores. In 1937 the price of radium ((US$|25000|1937))((nbsp))per((nbsp))gram,((r|Time_1937)) and the total worldwide supply of radium available for beam radiotherapy (teletherapy) was 50((nbsp))grams.

The invention of the [[nuclear reactor]] in the [[Manhattan Project]] during World War II made possible the creation of artificial radioisotopes for radiotherapy. [[Cobalt-60]], produced by neutron irradiation of ordinary [[cobalt]] metal in a reactor, is a high activity gamma-ray emitter, emitting 1.17 and 1.33&nbsp;MeV gamma rays with an activity of ((convert|44|TBq/g|Ci/g|abbr=on|lk=on)).  The main reason for its wide use in radiotherapy is that it has a longer [[half-life]], 5.27&nbsp;years, than many other gamma emitters. However, this half-life still requires cobalt sources to be replaced about every 5 years.

In 1949, Dr. [[Harold E. Johns]] of the [[University of Saskatchewan]] sent a request to the [[National Research Council (Canada)|National Research Council]] (NRC) of Canada asking it to produce cobalt-60 isotopes for use in a cobalt therapy unit prototype. Two cobalt-60 apparatuses were then built, one in [[Saskatoon]] in the cancer wing of the University of Saskatchewan and the other in [[London, Ontario]]. Johns collected depth-dose data at the University of Saskatchewan which would later become the world standard.((r|Cobal60_usask)) The first patient to be treated with cobalt-60 radiation was treated on October 27, 1951, at the [[Children's Hospital at London Health Sciences Centre|War Memorial Children's Hospital]] in London, Ontario.((r|HeritageAssessment2011))((r|LHSC_2011)) In 1961 cobalt therapy was expected to replace X-ray radiotherapy.((r|SydneyMorningHerald_1961))((rp|page=14)) In 1966, [[Walt Disney]]'s lung cancer was treated with this procedure, but could not prevent his death.((r|Markel_Disney_2018)) 

Dr. [[Glenn T. Seaborg]], chairman of the [[United States Atomic Energy Commission]], [[Nobel Prize]] winner and former chancellor of the [[University of California]], dedicated the first cobalt facility of the new Radiation Therapy and Nuclear Medicine Wing of the [[Cedars of Lebanon Hospital]] on January 11, 1963 supervised by Dr. Henry L. Jaffe, Director of the new department. A pioneer in the use of the nicknamed "cobalt bomb" the Cedars unit was licensed in 1948 by the Atomic Energy Commission.<ref>((cite web |title=Nuclear Medicine Dedication At Cedars Hospital |url=https://www.nli.org.il/en/newspapers/bbh/1963/01/11/01/article/20/?e=-------en-20--1--img-txIN%7ctxTI--------------1 |website=National Library of Israel |publisher=B'nai B'rith Messenger, January 11 1963 |access-date=13 July 2022))</ref>

==Current use==
The role of the cobalt unit has partly been replaced by the [[Linear particle accelerator#Medical linacs|linear accelerator]], which can generate higher-energy radiation, and does not produce the [[radioactive waste]] that [[radioisotope]]s do with their attendant disposal problems. Cobalt treatment still has a useful role to play in certain applications and is still in widespread use worldwide, since the machinery is relatively reliable and simple to maintain compared to the modern linear accelerator.<ref>((Cite web|url=https://www.redjournal.org/article/S0360-3016(13)03678-X/fulltext|title=Cobalt, Linac, or Other: What Is the Best Solution for Radiation Therapy in Developing Countries? - International Journal of Radiation Oncology, Biology, Physics))</ref><ref name="auto"/>

==Isotope==
As used in [[External beam radiotherapy#X-rays and gamma rays|radiotherapy]], cobalt units produce stable, dichromatic beams of 1.17((nbsp))and((nbsp))1.33 MeV, resulting in an average beam energy of 1.25((nbsp))MeV. Cobalt-60 has a [[half-life]] of 5.2713((nbsp))years.((r|ICRP107))((rp|page=39))

==See also==
*[[Gamma knife]]

==References==
((Reflist|30em|refs=

<ref name="Time_1937">((cite magazine | author = <!--Staff writer(s); no by-line.--> | date = 1937-08-09 | title = Science: Radium | url = https://content.time.com/time/subscriber/article/0,33009,758086,00.html 
| url-status = live | magazine = [[Time (magazine)|Time]] | language = en-US | issn = 0040-781X | oclc = 1311479 | archive-url = https://web.archive.org/web/20220622155908/https://content.time.com/time/subscriber/article/0,33009,758086,00.html | archive-date = 2022-06-22 | access-date = 2022-06-22 | quote = Present price of radium is $25 per milligram, $25,000 per gram, $700,000 per ounce. | df = dmy-all ))</ref>

<ref name="Cobal60_usask">((cite web |url = https://cobalt60.usask.ca/ |title = Cobalt-60: Explore our legacy of nuclear medicine innovation | website = [[University of Saskatchewan]] | date = n.d. | access-date = 2022-06-22 | archive-url = https://web.archive.org/web/20220308050325/https://cobalt60.usask.ca/ | archive-date = 2022-03-08 | url-status = live | quote = In 1951, University of Saskatchewan medical physicist Dr. Harold Johns and his graduate students became the first researchers in the world to successfully treat a cancer patient using cobalt-60 radiation therapy. This innovative technology—dubbed the “cobalt bomb” by the media—revolutionized cancer treatment and saved the lives of millions of cancer patients around the world. | df = dmy-all ))</ref>

<ref name="HeritageAssessment2011">
((cite web     
| url         = https://www.london.ca/business/Planning-Development/secondary-plans/Documents/Old%20Victoria%20Hospital/Cultural-Heritage-Asssessment-South-Street-Hospital-Buildings.pdf#page=46
| title       = Cultural Heritage Assessment: Buildings in the South Street Hospital Complex, London, Ontario 
| author      = 
| date        = 
| page        = 46
| location    = 
| isbn        = 
| language    = 
| trans-title = 
| archive-url  = https://web.archive.org/web/20200504041250/https://www.london.ca/business/Planning-Development/secondary-plans/Documents/Old%20Victoria%20Hospital/Cultural-Heritage-Asssessment-South-Street-Hospital-Buildings.pdf#page=46
| archive-date = 2020-05-04
| access-date  = 2020-05-03
| url-status  = live
| quote       = It is perhaps fitting, given the symbolic emphasis that the War Memorial Children’s Hospital placed on turning the spoils of war to the benefits of peace, that this facility became the first place in the world to use the Cobalt-60 Beam Therapy Unit (the Cobalt Bomb) in the treatment of a Cancer patient, on October 27, 1951. 
))</ref>

<ref name="LHSC_2011">((cite web | url = https://www.lhsc.on.ca/about-lhsc/celebrating-the-60th-anniversary-of-the-worlds-first-cancer-treatment-with-cobalt-60 | title = Celebrating the 60th anniversary of the world's first cancer treatment with Cobalt-60 radiation | date = 2011-10-27 | website = [[London Health Sciences Centre]] | language = en-CA | access-date = 2022-06-23 | url-status = live | archive-url = https://web.archive.org/web/20220427192817/https://www.lhsc.on.ca/about-lhsc/celebrating-the-60th-anniversary-of-the-worlds-first-cancer-treatment-with-cobalt-60 | archive-date = 2022-04-27 | quote = On October 27, 1951, the world's first cancer treatment with Cobalt-60 radiation took place at Victoria Hospital. This marked an important milestone for both the fight against cancer and Canada's emergence as a leader in the field of radiotherapy. Today, London Health Sciences Centre is pleased to acknowledge the 60th anniversary of this tremendous medical breakthrough. | df = dmy-all ))</ref>

<ref name="SydneyMorningHerald_1961">((cite news | author = <!-- not stated --> | date = 1961-11-01 | title = "New Era" In Cobalt Treatment Of Cancer | url = https://news.google.com/newspapers?nid=1301&dat=19611101&id=DIgVAAAAIBAJ&sjid=RuYDAAAAIBAJ&pg=790,7885261 | url-status = live | work = [[The Sydney Morning Herald]] | language = en-AU | issue = 29649 | edition = Late | page = 14 | issn = 0312-6315 | lccn = sn84035933 | oclc = 226369741 | archive-url = https://web.archive.org/web/20220528151121/https://news.google.com/newspapers?nid=1301&dat=19611101&id=DIgVAAAAIBAJ&sjid=RuYDAAAAIBAJ&pg=790,7885261 | archive-date = 2022-05-28 | access-date = 2022-06-23 | via = [[Google News]] |df = dmy-all))</ref>

<ref name="Markel_Disney_2018">((cite news | last1 = Markel | first1 = Howard | date = 2018-12-17 | title = How a strange rumor of Walt Disney's death became legend | url = https://www.pbs.org/newshour/health/how-a-strange-rumor-of-walt-disneys-death-became-legend | url-status = live | department = Health | work = [[PBS NewsHour]] | language = en-US | archive-url = https://web.archive.org/web/20220618120446/https://www.pbs.org/newshour/health/how-a-strange-rumor-of-walt-disneys-death-became-legend | archive-date = 2022-06-18 | access-date = 2022-06-23 | quote = The always energetic man struggled to go back to the Disney studios after the operation, but the chemotherapy and cobalt X-ray treatments drained him of both his creative and physical powers. He was rushed back to St. Joseph's Hospital two weeks later and died of "circulatory collapse" on the morning of Dec. 15. | df = dmy-all ))</ref>

<ref name="ICRP107">((cite book | chapter = Annex A. Radionuclides of the ICRP-07 collection | title = Annals of the ICRP ((!)) Nuclear Decay Data for Dosimetric Calculations | publisher = [[International Commission on Radiological Protection]] | date = 2008 | volume = 38 | series = ICRP Publication 107 | issue = 3 | pages = 35–96 | doi = 10.1016/j.icrp.2008.10.002 | doi-access = free | issn = 0146-6453 | isbn = 978-0-7020-3475-6 | lccn = 78647961 | pmid = 19285593 | last1 = Eckerman | first1 = K. | last2 = Endo | first2 = A. ))</ref>

))

==External links==
*[http://visualsonline.cancer.gov/details.cfm?imageid=1819 public domain image of cobalt machine]

[[Category:Radiation therapy]]
[[Category:Cobalt]]

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