Codoxime
Clinical data

Other names	Codoxime
ATC code	none
Legal status
Legal status	BR: Class A1 (Narcotic drugs)^[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) UN: Narcotic Schedule I
Identifiers
IUPAC name (((4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ylidene)amino)oxy)acetic acid
CAS Number	7125-76-0
PubChem CID	9570253
ChemSpider	7844721
UNII	JT5I2F57F7
KEGG	D03581
ChEMBL	ChEMBL2107300
ECHA InfoCard	100.027.660
Chemical and physical data
Formula	C₂₀H₂₄N₂O₅
Molar mass	372.421 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)CO\N=C4\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects^[2] and was found to have moderate potential to cause dependence in animal studies.^[3]

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ US granted 3153042, Jack Fishman, "Morphinone and Codeinone Derivatives", issued 13 October 1964, assigned to Mozes Juda Lowenstein
^ Jasinski DR, Martin WR (1967). "Assessment of the dependence-producing properties of dihydrocodeinone and codoxime". Clinical Pharmacology and Therapeutics. 8 (2): 266–70. doi:10.1002/cpt196782266. PMID 6021586. S2CID 36504901.