Coffey (/ˈkoʊfi/, /ˈkɒfi/) is an Irish surname, from Ó Cobhthaigh. Notable people with the surname include:

• Aeneas Coffey (1780–1852), Irish inventor
• Amir Coffey (born 1997), American basketball player
• Ann Coffey (born 1946), British politician
• Brent Coffey (born 1975), American Peer Reviewed Cancer Researcher
• Brian Coffey (1905–1995), Irish poet
• Cath Coffey, British vocalist of Stereo MC's
• Charles Coffey (?–1745), Irish playwright
• Denise Coffey (1936–2022), British actress
• Dennis Coffey, American guitarist
• Ellie-Jean Coffey, Australian surfer, model, and actress
• George Nelson Coffey (1875−1967), American pedologist
• Greg Coffey (born 1971), Australian London-based hedge fund manager
• Jack Coffey (baseball) (1887–1966), Major League Baseball player
• John Coffey (disambiguation), several people
• Joseph L. Coffey, Roman Catholic Bishop of the Archdiocese for the Military Services, USA
• Kellie Coffey (born 1971), American singer-songwriter
• Michael J. Coffey (c. 1840 – 1907), New York politician
• Paul Coffey (born 1961), Canadian hockey player
• Peter Coffey (1876–1943), Irish Roman Catholic priest and Neoscholastic philosopher
• Russell Coffey (1898–2007), one of the last three surviving American World War I veterans
• Seamus Coffey – Irish economist
• Sean Coffey (born 1956), New York lawyer
• Susanna Coffey, American artist
• Tabatha Coffey, Australian hairstylist
• Tāmati Coffey (born 1979), New Zealand broadcaster and politician
• Thérèse Coffey, British Conservative Member of Parliament
• Todd Coffey (born 1980), Major League Baseball relief pitcher
• Victoria Coffey (1911–1999), Irish paediatrician
• Virginia Coffey (1904–2003), American civil rights activist
• Wayne Coffey (footballer) (born 1964), American football player
• William Coffey (VC) (1829–1875), Irish Victoria Cross recipient
• William Coffey (cricketer) (born 1885, date of death unknown), Irish cricketer