The team reopens the 1988 murder of Jimmy Tate, an 18-year-old high school student and young father who was killed in a hit-and-run accident on graduation night, after his daughter is contacted by a man claiming to be her biological father.

The team reopens the 2004 murder of Laurie Dunne, an 18-year-old college student who died of suffocation in a fraternity house fire after her widowed father presents evidence suggesting her death was not accidental. The team discovers that the young woman was targeted by fraternity members due to being overweight.

The team reopens the 1978 murder of Angus Bistrong, a 21-year-old college student who was stabbed to death and his body left in front of a movie theater after his mother finds a letter suggesting that his death wasn't random. The team discovers that many of his friends blamed him for a car accident that left their other friend disabled.

Encouraged by Jefferies’ nephew, the team reopens the 1945 murder of Clyde Taylor, a 20-year-old African-American baseball player who was supposed to play in the Major Leagues, but was beaten to death with his own baseball bat.

When it is discovered that a recently deceased elderly woman had been using someone else's identity for decades, the team reopens the 1954 death of Bettie Petrowski, a housewife who was committed to a mental institution after nearly burning her son in a house fire. When her son identifies her body among other Jane Doe cases, the team discovers she was lobotomized before being left for dead in a snowstorm.

After Maeve Bubley, a mother of five boys loses her fourth son to gang violence, the team reopens the 1999 murder of her first son, Vaughn, one of Rush's first cases as a homicide detective, along with the murders of her three other sons: Cedric in 2001, Quincy in 2003, and the most recent, Luther in 2005. The team is determined to track down the killer of the mother's first four sons in order to save her last remaining one, Patrick.

The team reinvestigates the 1999 death of Amy Lind, a young, healthy woman who seemingly died of a heart attack, after a death threat addressed to her is found on the hard drive of an old computer. The team discovers that the victim was briefly a millionaire during the dot-com boom, but her company went under due to her partner's indulgent behavior and an investor's unscrupulous practices.

The team reopens the 1973 murder of Carl Burton, a 35-year-old veteran of the Vietnam War who was shot to death a year after he came home from the notorious Hanoi Hilton, after a box filled with POW support bracelets is found in an abandoned drug den. The team soon learns dark secrets about his return and discovers that his murder may have been an act of revenge.

The team reopens the 1965 disappearance of Vivian Mulvaney, a 4-year-old girl after her remains wash up on a New Jersey shore. The team discovers that she came from an abusive household, and their investigation uncovers the domestic violence that took place in her home.

The team re-opens the 2001 murder of Frank DiCenzio, a 49-year-old widowed deli owner, when the brother of the man convicted of the murder brings forth new evidence suggesting that his brother may be innocent. The team discovers that the victim had a rocky personal life following the death of his wife.

The team reopens the 1988 murder of Clem Garris after receiving an anonymous tip related to his murder. The top suspects include three of the victim's old friends who had parted ways after graduating from high school eight years before his death.

The team reopens the 1994 death of Trevor Dawson, a 16-year-old boy who was an outcast in school who fell to his death from the roof of his school after serving detention on the same day. The death was originally ruled a suicide, but a newly-found piece of his suicide note indicates that he may have been fearing for his life prior to this death.

The team reopens the 1968 death of Emma Vine, an 18-year-old girl who died the night of her debutante ball. The death was originally ruled accidental, but the victim's mother comes forward with new evidence after the wife of the man who had escorted the victim to the ball dies in an identical fashion.

The team reopens the 2000 murder of Roween Ryan, a 30-year-old bank teller who was killed during a robbery, after the same bank is robbed again by perpetrators wearing identical masks and equipped with identical weapons. The team soon discovers that the victim might have been dating one of the suspects prior to the robbery and that she was possibly involved herself.

After a notorious drug dealer is arrested, the team reopens the 1998 murder of Ana Castilla, a Hispanic woman found eviscerated in an alleyway, who had worked for the dealer as a drug mule. The case soon takes a personal turn when the team learns Scotty had a close relationship with Ana prior to her death while he was undercover.

The team reinvestigates the 1980 murder of Steve Jablonski, a 17-year-old boy who was buried alive on the night of his prom, after the killer turns himself in and claims to have struck again. The team races against time to discover the man's MO in order to locate the latest victim before it is too late.

The team reinvestigates the 1973 murder of Andi Simmons, a 18-year-old college tennis star who was strangled to death hours after winning a "Battle of the Sexes" match, after the victim's sister presents evidence suggesting that someone had been trying to poison her prior to the match. The investigation uncovers her life wasn't picture perfect with several people harboring resentment towards her, including her own father.

The team reopens the 2002 murder of Dennis Hofferman (Adam Pascal), a 35-year-old outcast taxi driver who had just been cast for his first role in a musical, after a gun is found amongst prop furniture at a local community theater.

The team reopens the 1929 murder of Violet Polley, a 20-year-old woman and young mother who was found dead in a ravine on Christmas Day, when the victim's great-granddaughter asks the team to finally solve the case in order to clear away the dark cloud hovering over her family.

The team reopens the 1994 rape and murder of Kate Lange, a 16-year-old girl after the man who is about to be executed for the murder tells Det. Jeffries that he was set up by one of the detectives who had originally investigated the case. The team discovers that they may be too late to save the man, due to an arrogant ADA stonewalling them.

The team reopens the 1945 murder of an ambitious female reporter, Lorena "Lo" Kinney, who was thought to have died in a purse snatching gone wrong, after a letter turns up indicating that she was meeting someone at the same train station the night she died.

The team reopens the 1984 murder of Grant Bowen, a respected and beloved ER doctor, after a new witness comes forward saying that he was with a fellow hospital employee just before his death. The team discovers that the victim had a secret gambling addiction that was destroying his family.

The team reopens the 2005 murder of Joseph Shaw, a drug counselor at a teens' rehab center who was shot to death two weeks before he was scheduled to testify in a murder case, after his credit card is used. Lilly finds herself inexplicably drawn to the victim and sets out to investigate a farmhouse where Joseph once stayed, where she makes a shocking discovery.