CDSN
Identifiers
Aliases	CDSN, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
External IDs	OMIM: 602593 HomoloGene: 48005 GeneCards: CDSN
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,115,087 bp[1] End 31,120,446 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen placenta gastrocnemius muscle vagina skeletal muscle tissue thymus gallbladder duodenum left ventricle right lobe of liver n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Cellular component extracellular region desmosome cell-cell junction cornified envelope plasma membrane Biological process cell adhesion skin morphogenesis keratinocyte differentiation epidermis development cornification corneocyte desquamation negative regulation of cornification cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1041 n/a Ensembl ENSG00000204539 n/a UniProt Q15517 n/a RefSeq (mRNA) NM_001264 n/a RefSeq (protein) NP_001255 n/a Location (UCSC) Chr 6: 31.12 – 31.12 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.^[3][4][5]

This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.^[5]