This is a list of people who have served as Custos Rotulorum of Derbyshire.

• Sir John Vernon bef. 1544 – aft. 1544
• Sir Francis Leke bef. 1547 – bef. 1580
• Sir John Manners 1580–1611
• George Manners bef. 1617–1617
• William Cavendish, 2nd Earl of Devonshire 1617–1628
• Edward Sackville, 4th Earl of Dorset 1628–1646
• Interregnum
• William Cavendish, 1st Duke of Newcastle 1660–1676
• Henry Cavendish, 2nd Duke of Newcastle 1677–1689
• William Cavendish, 1st Duke of Devonshire 1689–1707

For later custodes rotulorum, see Lord Lieutenant of Derbyshire.