CCNE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W98
Identifiers
Aliases	CCNE1, CCNE, pcyclin E1
External IDs	OMIM: 123837 MGI: 88316 HomoloGene: 14452 GeneCards: CCNE1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q12 Start 29,811,991 bp[1] End 29,824,312 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 25.35 cM Start 37,797,409 bp[2] End 37,806,959 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte placenta bone marrow amniotic fluid spongy bone stromal cell of endometrium bone marrow cells cerebellar hemisphere rectum embryo Top expressed in morula condyle fossa internal carotid artery primitive streak somite yolk sac maxillary prominence external carotid artery Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding androgen receptor binding protein kinase binding cyclin-dependent protein serine/threonine kinase activity protein kinase activity Cellular component cytosol cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus cyclin E1-CDK2 complex cytoplasm centrosome Biological process androgen receptor signaling pathway Wnt signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of cell cycle cell division positive regulation of transcription, DNA-templated protein phosphorylation DNA replication initiation cell cycle regulation of protein kinase activity negative regulation of transcription by RNA polymerase II telomere maintenance homologous chromosome pairing at meiosis chromosome organization involved in meiotic cell cycle G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle positive regulation of G1/S transition of mitotic cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 898 12447 Ensembl ENSG00000105173 ENSMUSG00000002068 UniProt P24864 Q61457 RefSeq (mRNA) NM_001238 NM_057182 NM_001322259 NM_001322261 NM_001322262 NM_007633 RefSeq (protein) NP_001229 NP_001309188 NP_001309190 NP_001309191 NP_001309188.1 NP_001309190.1 NP_031659 Location (UCSC) Chr 19: 29.81 – 29.82 Mb Chr 7: 37.8 – 37.81 Mb PubMed search [3] [4]
Wikidata
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G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.^[5]

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.^[6]

Interactions

Cyclin E1 has been shown to interact with: