cyclin E2
Identifiers
SymbolCCNE2
NCBI gene9134
HGNC1590
OMIM603775
RefSeqNM_057749
UniProtO96020
Other data
LocusChr. 8 q22.1
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StructuresSwiss-model
DomainsInterPro

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]

References

  1. ^ a b Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.
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