CCNH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JKW, 1KXU
Identifiers
Aliases	CCNH, CAK, CycH, p34, p37, Cyclin H
External IDs	OMIM: 601953 MGI: 1913921 HomoloGene: 946 GeneCards: CCNH
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.3 Start 87,318,416 bp[1] End 87,412,930 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 85,337,527 bp[2] End 85,371,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence anterior pituitary right lung sperm tibial nerve cerebellar hemisphere bone marrow cells Brodmann area 9 left uterine tube Top expressed in interventricular septum fossa condyle vas deferens primitive streak facial motor nucleus otic placode Paneth cell internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP-dependent activity, acting on DNA kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity Cellular component nucleoplasm transcription factor TFIIH holo complex transcription factor TFIIK complex nucleus cyclin-dependent protein kinase activating kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex Biological process termination of RNA polymerase I transcription regulation of transcription, DNA-templated phosphorylation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated positive regulation of phosphorylation of RNA polymerase II C-terminal domain positive regulation of cyclin-dependent protein serine/threonine kinase activity cell cycle transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II protein phosphorylation nucleotide-excision repair, preincision complex assembly protein stabilization regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 902 66671 Ensembl ENSG00000134480 ENSMUSG00000021548 UniProt P51946 Q61458 RefSeq (mRNA) NM_001199189 NM_001239 NM_001363539 NM_001364075 NM_001364076 NM_023243 NM_001347587 NM_001347588 RefSeq (protein) NP_001186118 NP_001230 NP_001350468 NP_001351004 NP_001351005 NP_001334516 NP_001334517 NP_075732 Location (UCSC) Chr 5: 87.32 – 87.41 Mb Chr 13: 85.34 – 85.37 Mb PubMed search [3] [4]
Wikidata
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Cyclin-H is a protein that in humans is encoded by the CCNH gene.^[5][6]

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.^[6]

Interactions

Cyclin H has been shown to interact with P53,^[7] Cyclin-dependent kinase 7^[8][9][10] and MNAT1.^[11][12]