DEK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q1V, 2JX3
Identifiers
Aliases	DEK, D6S231E, DEK proto-oncogene
External IDs	OMIM: 125264 MGI: 1926209 HomoloGene: 2593 GeneCards: DEK
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 18,223,860 bp[1] End 18,264,548 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 24.5 cM Start 47,238,251 bp[2] End 47,259,677 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibia ganglionic eminence spongy bone amniotic fluid germinal epithelium jejunal mucosa lactiferous duct monocyte visceral pleura Top expressed in secondary oocyte bone marrow thymus yolk sac ovary uterus spleen lung neural tube stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone binding chromatin binding RNA binding Cellular component nucleoplasm contractile fiber nucleus Biological process epigenetic maintenance of chromatin in transcription-competent conformation viral genome replication regulation of double-strand break repair via nonhomologous end joining transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of double-strand break repair signal transduction chromatin remodeling chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7913 110052 Ensembl ENSG00000124795 ENSMUSG00000021377 UniProt P35659 Q7TNV0 RefSeq (mRNA) NM_001134709 NM_003472 NM_025900 RefSeq (protein) NP_001128181 NP_003463 NP_080176 Location (UCSC) Chr 6: 18.22 – 18.26 Mb Chr 13: 47.24 – 47.26 Mb PubMed search [3] [4]
Wikidata
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The human DEK gene encodes the DEK protein.^[5][6]

Function

This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.^[6]

Interactions

DEK interacts with TFAP2A.^[7]