DHX29
Identifiers
Aliases	DHX29, DDX29, DEAH-box helicase 29, DExH-box helicase 29
External IDs	OMIM: 612720 MGI: 2145374 HomoloGene: 10387 GeneCards: DHX29
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,256,055 bp[1] End 55,307,694 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 113,063,988 bp[2] End 113,105,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva secondary oocyte visceral pleura seminal vesicula parietal pleura tibia germinal epithelium gums biceps brachii Achilles tendon Top expressed in superior cervical ganglion hand foot otolith organ utricle oocyte interventricular septum maxillary prominence secondary oocyte primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function translation initiation factor activity ATP binding hydrolase activity nucleotide binding nucleic acid binding helicase activity ribosomal small subunit binding cadherin binding RNA binding RNA helicase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3'-5' RNA helicase activity Cellular component cytoplasm eukaryotic 43S preinitiation complex mitochondrion Biological process RNA processing translational initiation protein biosynthesis positive regulation of translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54505 218629 Ensembl ENSG00000067248 ENSMUSG00000042426 UniProt Q7Z478 Q6PGC1 RefSeq (mRNA) NM_019030 NM_001345964 NM_001345965 NM_172594 RefSeq (protein) NP_001332893 NP_001332894 NP_061903 NP_766182 Location (UCSC) Chr 5: 55.26 – 55.31 Mb Chr 13: 113.06 – 113.11 Mb PubMed search [3] [4]
Wikidata
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DExH-box helicase 29 (DHX29) is a 155 kDa protein that in humans is encoded by the DHX29 gene.^[5]

Function

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection.^[6] This protein may also play a role in sensing virally derived cytosolic nucleic acids.^[7] Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.^[8]

Interactions

DHX29 has been shown to interact with the eukaryotic small ribosomal subunit (40S) and eIF3.^{[9][10][11][12]}