DIAPH2
Identifiers
Aliases	DIAPH2, DIA, DIA2, DRF2, POF, POF2, diaphanous related formin 2, POF2A
External IDs	OMIM: 300108 HomoloGene: 136807 GeneCards: DIAPH2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.33 Start 96,684,712 bp[1] End 97,604,997 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura bronchial epithelial cell lower lobe of lung visceral pleura hair follicle Achilles tendon placenta sperm parotid gland vastus lateralis muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding signaling receptor binding Cellular component cytoplasm cytosol endosome early endosome nucleolus intracellular membrane-bounded organelle endoplasmic reticulum Biological process multicellular organism development cell differentiation female gamete generation actin cytoskeleton organization actin filament organization oogenesis cellular component organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1730 n/a Ensembl ENSG00000147202 n/a UniProt O60879 n/a RefSeq (mRNA) NM_007309 NM_006729 n/a RefSeq (protein) NP_006720 NP_009293 n/a Location (UCSC) Chr X: 96.68 – 97.6 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Protein diaphanous homolog 2 is a protein that in humans is encoded by the DIAPH2 gene.^[3][4]

Function

This gene may play a role in the development and normal function of the ovaries. Mutations of this gene have been linked to premature ovarian failure. Alternative splicing results in two protein isoforms.^[4]

Interactions

DIAPH2 has been shown to interact with RhoD.^[5]