|Chemical and physical data|
|Molar mass||228.12 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
DOV 216,303 is an experimental antidepressant drug originally developed by DOV Pharmaceutical and was licensed to Merck & Co. in 2004; Merck and DOV terminated their relationship in December 2006.: 12 
It is a triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV-21,947) and its (–)-enantiomer, DOV-102,677. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively.
As of March 2008, DOV had no intention to further develop DOV-216,303 because the patent on the compound had expired.: 6
In a mouse model, DOV-216,303 has shown the ability to promote recovery after spinal cord contusion.
DOV 216,303 was originally in development for depression; however as the patented composition of matter claim has expired, there are no ongoing clinical trials of DOV 216,303 and none are planned.