DPP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FVY, 3T6B, 3T6J, 5E2Q, 5EHH, 5E33, 5E3C, 5E3A, 5EGY
Identifiers
Aliases	DPP3, DPPIII, dipeptidyl peptidase 3
External IDs	OMIM: 606818 MGI: 1922471 HomoloGene: 40210 GeneCards: DPP3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,480,013 bp[1] End 66,509,657 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,957,257 bp[2] End 4,978,315 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte rectum islet of Langerhans secondary oocyte stromal cell of endometrium right adrenal gland gallbladder monocyte body of stomach gastrocnemius muscle Top expressed in yolk sac lip primitive streak esophagus neural tube lacrimal gland seminal vesicula renal corpuscle proximal tubule spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding peptidase activity aminopeptidase activity protein binding hydrolase activity metallopeptidase activity dipeptidyl-peptidase activity metal ion binding Cellular component plasma membrane extracellular exosome cytoplasm nuclear speck cytosol Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10072 75221 Ensembl ENSG00000254986 ENSMUSG00000063904 UniProt Q9NY33 Q99KK7 RefSeq (mRNA) NM_130443 NM_001256670 NM_005700 NM_133803 NM_001360711 RefSeq (protein) NP_001243599 NP_005691 NP_569710 NP_598564 NP_001347640 Location (UCSC) Chr 11: 66.48 – 66.51 Mb Chr 19: 4.96 – 4.98 Mb PubMed search [3] [4]
Wikidata
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Dipeptidyl-peptidase 3 is an enzyme that in humans is encoded by the DPP3 gene.^[5][6]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.^[7]