DUSP12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JNB, 4KI9
Identifiers
Aliases	DUSP12, DUSP1, YVH1, dual specificity phosphatase 12
External IDs	OMIM: 604835 MGI: 1890614 HomoloGene: 5238 GeneCards: DUSP12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,749,758 bp[1] End 161,757,238 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,873,498 bp[2] End 170,885,540 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte cerebellar hemisphere embryo cerebellar vermis ganglionic eminence lymph node monocyte left coronary artery superficial temporal artery right coronary artery Top expressed in secondary oocyte morula neural tube yolk sac endocardial cushion ileum proximal tubule superior frontal gyrus fossa renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity metal ion binding zinc ion binding phosphatase activity nucleic acid binding kinase binding Cellular component cytosol nucleus cytoplasm Biological process protein dephosphorylation positive regulation of glucokinase activity peptidyl-tyrosine dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11266 80915 Ensembl ENSG00000081721 ENSMUSG00000026659 UniProt Q9UNI6 Q9D0T2 RefSeq (mRNA) NM_007240 NM_023173 RefSeq (protein) NP_009171 NP_075662 NP_001343414 NP_001343415 Location (UCSC) Chr 1: 161.75 – 161.76 Mb Chr 1: 170.87 – 170.89 Mb PubMed search [3] [4]
Wikidata
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Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.^[5][6]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.^[6]