DUSP16
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDUSP16, MKP-7, MKP7, dual specificity phosphatase 16
External IDsOMIM: 607175 MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16
Orthologs
SpeciesHumanMouse
Entrez

80824

70686

Ensembl

ENSG00000280962
ENSG00000111266

ENSMUSG00000030203

UniProt

Q9BY84

n/a

RefSeq (mRNA)

NM_030640

NM_001048054
NM_130447
NM_181320

RefSeq (protein)

NP_085143
NP_085143.1

n/a

Location (UCSC)Chr 12: 12.47 – 12.56 MbChr 6: 134.69 – 134.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[5][6][7][8]

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][8]

Interactions

DUSP16 has been shown to interact with MAPK14[9][10] and MAPK8IP1.[11]

References

  1. ^ a b c ENSG00000111266 GRCh38: Ensembl release 89: ENSG00000280962, ENSG00000111266 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030203 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
  6. ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. PMID 11489891.
  7. ^ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem. 280 (27): 25651–8. doi:10.1074/jbc.M501926200. PMID 15888437.
  8. ^ a b "Entrez Gene: DUSP16 dual specificity phosphatase 16".
  9. ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
  10. ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. United States. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. ISSN 0021-9258. PMID 11489891.
  11. ^ Willoughby EA, Perkins Gordon R, Collins Mary K, Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. United States. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447.

Further reading

External links



Esterase: protein tyrosine phosphatases (EC 3.1.3.48)
Categories