| Dwarfin sma | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-8 | ||||||
| Entrez | 187612 | ||||||
| RefSeq (mRNA) | NM_059920.3 | ||||||
| RefSeq (Prot) | NP_492321.1 | ||||||
| UniProt | Q21733 | ||||||
| Other data | |||||||
| Chromosome | I: 8.58 - 8.59 Mb | ||||||
| |||||||
The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.[1] When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[2]