The Daniel Legare House is the oldest surviving house in the historic Ansonborough area of Charleston, South Carolina.^[1] The land upon which the house was built was sold to Daniel Crawford in May 1745 for a price that was much lower than expected for a house at the time, thereby suggesting a construction date after that time.^[1]

When Crawford's estate sold the property in 1760, the deed included a reference to buildings on the grounds.^[1] Details about the house suggest two different construction periods.^[1] For example, there are breaks in the vertical woodwork between the second (main entrance) floor and the third floor, suggesting that the third floor is a later addition.^[1] Daniel Crawford possibly erected the roughly finished basement and first floor of the house while Daniel Legare, a man of means, perhaps expanded the house by adding the upper floor.^[1]

Later owners included Bishop William May Wightman. Wightman served as the first president of Wofford College.^[2]