Dave or David Mat(t)hews may refer to:

Music

• Dave Matthews (born 1967), lead singer and guitarist of the pop music group Dave Matthews Band
• Dave Matthews (saxophonist) (1911–1997), American jazz saxophonist
• David Matthews (keyboardist) (born 1942), U.S. jazz composer, arranger, and keyboardist
• David Matthews (composer) (born 1943), English composer

Politics

• David Mathews (c. 1739–1800), mayor of New York City
• David Matthews (British politician) (1868–1960), MP for Swansea East
• F. David Mathews (born 1935), academic and politician

Sports

• David Matthews (rugby union) (1937–2019), rugby union flanker
• David Matthews (runner) (born 1974), Irish athlete
• David Mathews (field hockey) (born 1977), English field hockey player
• David Matthews (footballer) (born 1965), English footballer

Other

• David Matthews (author) (born 1967), American author
• David Matthews (blackjack player), American blackjack player and writer
• David Matthews (academic) (1932–2020), American and British scholar, author, and translator
• David A. Matthews (1847–1923), American soldier and Medal of Honor recipient
• Dave Matthews (Family Affairs), fictional character in the British TV soap opera Family Affairs