De Los Santos, also spelled delos Santos in the Philippines, is a Spanish surname meaning "of the saints". Notable people with the surname include:

• Abel De Los Santos (born 1992), American baseball player
• Alejandro de los Santos (1902–1982), Argentinian football player
• Enyel De Los Santos (born 1995), Dominican Republic baseball player
• Epifanio de los Santos (1871–1928), Filipino historian
• Fautino de los Santos (born 1986), Dominican Republic baseball player
• Gonzalo de los Santos (born 1976), Uruguayan football player
• Jaime de los Santos (born 1946), Filipino general
• Ramón de los Santos (1949—2015), Dominican Republic baseball player
• Valerio de los Santos (born 1972), Dominican Republic baseball player
• William de los Santos, (born 1964), actor
• Homer Delos Santos (born 1993), Project Evaluation Assistant in DENR - Environmental Management Bureau Solid Waste Management Division
• Yerry De Los Santos (born 1997), Dominican Republic baseball player
• Arvin De Los Santos (born 2000), artist from the Philippines