Set between the events of Dead Rising 2 and 3, the story continues where Watchtower left off. Chase catches Lyons' crimes on camera; however, his boss refused to broadcast it due to fear the military will come and kill them. Lyons sends his agents to kill Chase; however, Chase escapes. Garth is a skilled zombie killer and video game aficionado who talks a big and crude game to mask his gentle side. Rand is a handsome, cruel scientist who was hired by the government to find a cure for the raging zombie infection but instead is conducting horrendous experiments on the infected making the zombies faster and stronger. Sandra Lowe is a skilled computer hacker and Chase’s on-and-off girlfriend who joins him in his quest to battle the zombie-infested underground and stop General Lyons’ plan. George Hancock is the courageous whistleblower who compels Chase and his team to enter a zombie-infested city on a rescue mission. Jill is a news producer who joins Chase and his intrepid crew to infiltrate a secret laboratory and stop the carnage. Susan Ingot is the CEO of Phenotrans, the manufacturer of Zombrex, the vaccine that keeps the zombie infection at bay. It's revealed that Lyons and Phenotrans were behind the last outbreak at East Mission. Susan fears the military is planning to kill all the infected people and secretly plans a new zombie virus to stay in business. Chase and the others discover that Jordan is alive. Garth gets bitten by a fast zombie, which Zombrex cannot cure. George Hancock steals a new Zombie drug from Dr. Rand.
Chase and his allies stop the military's plan, causing General Lyons to flee. George Hancock escapes underground, but is shot by Lyons's agents. The new drug that George stole is now lost in the underground.
IGN awarded it a score of 6.7 out of 10, saying "Endgame strays further from its source material than the previous film, but it's also superior in terms of quality."[5]
