DBI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FJ9, 2CB8
Identifiers
Aliases	DBI, ACBD1, ACBP, CCK-RP, EP, Diazepam binding inhibitor, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor, acyl-CoA binding protein
External IDs	OMIM: 125950 MGI: 94865 HomoloGene: 39086 GeneCards: DBI
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.2 Start 119,366,924 bp[1] End 119,372,550 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 120,041,010 bp[2] End 120,048,808 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva sperm cavity of mouth human penis spinal cord body of tongue amygdala right lobe of liver ventral tegmental area endothelial cell Top expressed in optic nerve brown adipose tissue white adipose tissue subcutaneous adipose tissue medial ganglionic eminence left lobe of liver hair follicle kidney duodenum epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function benzodiazepine receptor binding lipid binding long-chain fatty acyl-CoA binding fatty-acyl-CoA binding protein dimerization activity Cellular component Golgi apparatus perinuclear endoplasmic reticulum extracellular exosome endoplasmic reticulum endoplasmic reticulum lumen Biological process protein palmitoylation phosphatidylcholine acyl-chain remodeling acyl-CoA metabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1622 13167 Ensembl ENSG00000155368 ENSMUSG00000026385 UniProt P07108 P31786 RefSeq (mRNA) NM_001079862 NM_001079863 NM_001178017 NM_001178041 NM_001178042 NM_001178043 NM_001282633 NM_001282634 NM_001282635 NM_001282636 NM_020548 NM_001352432 NM_001037999 NM_007830 RefSeq (protein) NP_001073331 NP_001073332 NP_001171488 NP_001171512 NP_001171513 NP_001171514 NP_001269562 NP_001269563 NP_001269564 NP_001269565 NP_065438 NP_001339361 NP_001033088 NP_031856 Location (UCSC) Chr 2: 119.37 – 119.37 Mb Chr 1: 120.04 – 120.05 Mb PubMed search [3] [4]
Wikidata
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Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.^[5][6]

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.^[6]