Doc or, less commonly, The Doc is the nickname of:

American Old West

• Doc Holliday (1851–1887), American gunfighter, gambler and dentist
• William Frank Carver (1851–1927), American sharpshooter and Wild West show producer
• Doc Scurlock (1849–1929), American cowboy and gunfighter
• David Swinson Maynard (1808-1873), American pioneer and businessman, founder of Seattle

Sports

• Doc Adams (1814–1899), American baseball player and executive
• Doc Adkins (1872–1934), American baseball player
• Doc Alexander (1897–1975), American NFL football player and coach
• Doc Amole (1878–1912), American baseball player
• Doc Ayers (1891–1968), American baseball player
• Darrel Baldock (1938–2011), Australian rules football player and coach and politician nicknamed "The Doc"
• Doc Baker (died c. early 1920s), African-American football player
• Doc Bass (1898–1970), American baseball player
• Doc Bennett (1891–1974), American baseball player and manager
• Doc Blanchard (1924–2009), American football player and fighter pilot
• Doc Casey (1870–1936), American Major League Baseball player and manager
• Matthew Clarke (Australian footballer) (born 1973), retired
• Doc Cook (baseball) (1886–1973), American Major League Baseball player
• L. J. Cooke (1868–1943), American college men's basketball coach
• Doc Crandall (1887–1951), American Major League Baseball player, the first used consistently as a relief pitcher
• Donald Dann (1949–2005), Australian Paralympic athlete
• Seán Doherty (Gaelic footballer) (born 1947), Irish former Gaelic football manager and player
• Ed Dougherty (born 1947), American golfer
• Doc Edwards (1936–2018), American Major League Baseball player
• Mike Emrick (born 1946), American hockey broadcaster
• Julius Erving (born 1950), American basketball player
• Doc Gautreau (1901–1970), American Major League Baseball player and manager
• Doc Gessler (1880–1924), American Major League Baseball player
• Dwight Gooden (born 1964), American Major League Baseball pitcher
• Doctor Greenwood (1860–1951), English footballer
• Roy Halladay (1977–2017), American Major League Baseball pitcher
• Dick Hoblitzell (1888–1962), American Major League Baseball player
• Arthur Irwin (1858–1921), Canadian-American Major League Baseball player and manager
• Jack Kearns (1882–1963), American boxing manager, most notably for Jack Dempsey
• Allan Kwartler (1917–1998), American sabre and foil fencer, Pan American Games and Maccabiah Games champion
• Doc Lawson (born 1958), American soccer player
• Doc MacKenzie (1906–1936), American race car driver
• Doc McJames (1874–1901), American baseball player and physician
• Walter Meanwell (1884–1953), college men's basketball coach
• Doc Medich (born 1948), American baseball player
• Cary Middlecoff (1921–1998), American golfer and dentist
• Donald Minnegan (1902–2002), former coach and athletic director at Towson University
• Gil Morgan (born 1946), American golfer
• Harold Nicholls (1897–1977), New Zealand rugby football player
• Danell Nicholson (born 1967), American former boxer
• Donncha O'Callaghan (born 1979), Irish rugby union footballer
• Derek Pace (1932–1989), English footballer
• Doc Powers (1870–1909), American Major League Baseball player and physician
• Doc Prothro (1893–1971), American Major League Baseball player and manager and dentist
• Doc Redman (born 1997), American golfer
• Ross Reynolds (1887–1970), American Major League Baseball pitcher
• Doc Rivers (born 1961), American National Basketball Association player and coach
• Johnny Rutherford (baseball) (1925–2016), Canadian former Major League Baseball pitcher
• Harry Sage (1864–1947), American Major League Baseball player
• Homer Smoot (1878–1928), American Major League Baseball player
• Gary Wiggins (1952–2008), Australian cyclist nicknamed "The Doc"
• Doc Wise (born 1967), American football player
• George Yeager (1874–1940), American Major League Baseball player

Arts and entertainment

• Doc Bagby, American musician
• Doc Brown (rapper) (born 1980), British rapper and comedian
• Doc Cheatham (1905–1997), American jazz trumpeter, singer and bandleader
• George Hager (1885–?), American illustrator and newspaper editorial cartoonist
• Doc Hammer, American musician and writer of The Venture Bros
• Owen Smith, Producer at game development company Uncommon Chocolate
• Harold L. Humes (1926–1992), American writer and activist
• Charles Kuhn (1892–1989), American cartoonist
• Doc Neeson (1947–2014), Irish-born Australian rock singer
• Doc Pomus (1925–1991), American blues singer and songwriter
• David G. Robinson (theatre pioneer), 19th century theatrical pioneer in Northern California
• Doc Searls (born 1947), American journalist, author and blogger
• Doc Severinsen (born 1927), American trumpeter and bandleader
• Doc Shaw (born 1992), American actor, singer and rapper
• Neil Simon (1927–2018), American playwright and screenwriter
• E. E. Smith (1890–1965), American science fiction writer
• Doc Watson (1923-2012), American musician and songwriter

Military

• John Bahnsen (born 1934), retired US Army brigadier general
• Donald E. Ballard (born 1945), American retired colonel and Medal of Honor recipient
• John Bradley (United States Navy) (1923–1994), US Navy corpsman who participated in the raising of the flag on Iwo Jima
• Donald M. Carpenter (1894–1940), early US Navy aviator
• Ivan Dougherty (1907–1998), Australian Army major general
• Ralph Eaton (1898–1986), US Army brigadier general
• Robert H. Foglesong (born 1945), retired US Air Force general
• Robert R. Ingram (born 1945), retired US Navy sailor and recipient of the Medal of Honor
• Charles R. Jennison (1834–1888), American Civil War colonel and anti-slavery activist
• Rick Jolly (1946–2018), former Royal Navy surgeon-captain nicknamed "The Doc"
• Wheeler Bryson Lipes (1920–2005), US Navy pharmacist's mate who performed the first major surgery aboard a submarine
• Harold Anthony Oaks (1896–1968), Canadian World War I flying ace
• Lewis Powell (conspirator) (1844–1865), Confederate soldier hanged for his part in the Abraham Lincoln assassination plot
• Alfred V. Rascon (born 1945), US Army retired lieutenant colonel and Medal of Honor recipient
• William P. Sanders (1833–1863), Union Army officer during the American Civil War

Politicians and government officials

• A. A. Ames (1842–1911), American politician
• David O. Cooke (1920–2002), American government administrator
• Charles Edgar Edgett (1883–1947), Canadian police chief and anti-communist
• H. V. Evatt (1894–1965), Australian politician
• Doc Hastings (1941-), American politician
• Robert Newell (politician) (1807–1869), American politician, fur trapper and frontier doctor
• Dennis O'Keefe (politician), former mayor of St. John's, Newfoundland and Labrador, Canada

Other

• Arthur Barker (1899–1939), American criminal, son of Ma Barker and a member of the Barker-Karpis gang
• John W. A. "Doc" Buyers (1928–2006), American business executive
• Ruben Cavazos (born 1957), American criminal, former International President of the Mongols Motorcycle Club
• Maurice Ewing (1906–1974), American geophysicist and oceanographer
• Michael Keiner (born 1959), German poker player and plastic surgeon nicknamed "The Doc"
• Doc Quigg (1911–1998), American journalist
• Maynard Jack Ramsay (1914–2005), American entomologist
• George M. Willing (1829–1874), American physician, prospector, and political lobbyist