Dreyfus is a surname. Notable people with the surname include:

Actors

• Alexandra Dreyfus (born 1986), American actress
• Chuckie Dreyfus (born 1974), Filipino actor
• James Dreyfus (born 1968), English actor
• Jean-Claude Dreyfus (born 1946), French actor
• Julie Dreyfus (born 1966), French actress
• Julia Louis-Dreyfus (born 1961), American actress and comedian
• Anouk Aimée (born Dreyfus, 1932), French actress

Other people

• Alfred Dreyfus (1859–1935), French Jewish military officer and focus of the Dreyfus affair
• Auguste Dreyfus (1827–1897), French guano merchant, financier
• Camille Dreyfus (chemist) (1878–1956), Swiss chemist
• Camille Ferdinand Dreyfus (1849–1915), French lawyer who was Senator for Seine-et-Oise from 1909 to 1915
• Charles Dreyfus (1848–1935), British-French Zionist and businessman
• Édouard Dreyfus Gonzalez (1876–1941) French lawyer and composer as "Jean Dora"
• Ferdinand-Camille Dreyfus (1851–1915), French journalist and politician
• Francis Dreyfus (1940–2010), French record producer, father of Julie Dreyfus
• George Dreyfus (born 1928), Australian composer, father of Mark Dreyfus
• Gérard Louis-Dreyfus (1932-2016), French-American businessman (Louis Dreyfus Group), father of Julia Louis-Dreyfus, cousin of Robert Louis-Dreyfus
• Harry Dreyfus (1891–1978), American businessman implicated in the Secret Court of 1920
• Henri Dreyfus (1882–1944), Swiss chemist and co-inventor of Celanese
• Hubert Dreyfus (1929–2017), American philosopher (University of California, Berkeley), brother of Stuart Dreyfus
• Huguette Dreyfus (1928–2016), French harpsichordist
• Jack Dreyfus (1913–2009), American financier, founder of the Dreyfus Corporation
• Jean-Marc Dreyfus, French historian
• Jérôme Dreyfus (born 1971), French judoka
• Karen Dreyfus, American violist
• Laurence Dreyfus (born 1952), American baroque music scholar and viol player
• Lee S. Dreyfus (1926–2008), American politician, Governor of Wisconsin (1979–1983)
• Mark Dreyfus (born 1956), Australian lawyer and politician, MP for Isaacs (2007–present), son of George Dreyfus
• Markus G. Dreyfus (1812-1877), Swiss Jewish teacher and publicist active in the struggle for the emancipation of Jews in Switzerland
• Max Dreyfus (1874–1964), German-born American music publisher
• Pablo Dreyfus (1969/70–2009), Argentine arms controller
• Philippe Dreyfus, French informatics pioneer
• Pierre Dreyfus (1907–1994), French civil servant, politician and businessman (Renault)
• René Dreyfus (1905–1993), French Grand Prix motor racing driver
• Robert Louis-Dreyfus (1946–2009), French businessman (Adidas-Salomon), cousin of Gérard Louis-Dreyfus
• Stuart Dreyfus, American academic, engineer and author (University of California, Berkeley), brother of Hubert Dreyfus
• Tony Dreyfus (1939–2023), French politician, Member of the National Assembly for Paris (1997–2012)
• Yves Dreyfus (1931–2021), French Olympic fencer

Fictional characters

• Chief Inspector Dreyfus, character in The Pink Panther film series
• Dreyfus, the main human antagonist in the 2014 film Dawn of the Planet of the Apes
• Shosanna [sic = Shoshanna] Dreyfus, one of the principal characters in Inglourious Basterds