"Super (Energy) Potion": Reiji Kirio, a Japanese salaryman, is transported to a different world where he opens a drug store in Kalta village to make and sell potions with werewolf girl Noela as store mascot, and ghost girl Mina Fleuret as shop assistant and housekeeper. Reiji creates a potion that cures exhaustion and is delicious, compared to most potions which are foul. Alf, the proprietor of a General Store, asks to be able to distribute the potion in his store, spreading word about the potion so both stores can make huge profits.

"Landenflower Tea": Reiji becomes involved in an argument between Zeral and his girlfriend Feris. Zeral explains Feris struggles to sleep and can be violently jealous, a borderline yandere and a worrywart. Reiji creates a medicinal drink called Landenflower Tea that reduces anxiety and aids sleep, since sleep deprivation causes mood swings. With Feris back to normal Zeral pays Reiji an exorbitant fee, revealing he is actually a rich, carefree noble. Reiji, a former downtrodden salaryman, becomes emotionally unstable at nobles throwing their money around, and the sweetness of the couple, forcing Mina to treat him with the tea as well.

"Botanical Deodorant": Noela finds an Utsubo flower which creates a stink detectable only to monsters, so Reiji brews a potion from flowers to neutralise the stink, accidentally inventing deodorant which is hugely popular with his customers.

"Dishwashing Detergent Scrubba-dub-dub": Reiji creates detergent to make cleaning easier for Mina. Doz and Moz, Red Cat mercenaries who protect the town, beg Reiji to sell his energy potions for a discount as their Captain Annabelle requires five a day due to how hard she works. Reiji agrees to provide them for free if they help advertise his detergent to the townspeople. Annabelle agrees after seeing how easily the detergent washes dishes and also insists on collecting her potions herself.

"Beast-Be-Gone": The forest begins running out of herbs so Reiji decides to grow them in fields loaned to him by Zeral, the Alonzo field. Unfortunately, pests have begun damaging crops so Reiji creates a beast repellent from the Utsubo flowers that repels the pests but is undetectable to humans. The repellant is an instant hit with farmers but Noela refuses to be around Reiji unless he has bathed first, due to her heightened sense of smell.

"Capshin Fluid": Annabelle reveals bandits have appeared recently and she needs extra potions for her injured soldiers. Reiji creates a potion from alcohol and Capshin Peppers which, when sprayed in the bandits faces causes unbearable pain in the eyes and nose. Shortly later, the bandits leave the area forever. Elsewhere, Reiji’s energy potion comes to the attention of someone powerful, the Demon Lord.

"Beautiful Belle's Beautiful Skin Gel": Reiji is asked by Lady Flam to create a rejuvenating potion as she can no longer stand her husband’s noble friends gossiping about how old she looks so Reiji creates moisturising face cream from fruits. With her skin looking much healthier Lady Flam is able to silence the bullying nobles so she sends Reiji expensive cookies in addition to his fee, causing Mina to think Lady Flam and Reiji are having an affair, thinking the gel as a gift to her.

"Charm Fragrance": Elaine, Lady Flam’s daughter, requests Reiji make a love potion to make Lord Lards, on whom she has a crush, fall in love with her. Reiji instead makes her a Charm Fragrance from flowers. Elaine, having become enamoured of Reiji’s talent and frank manner of speaking, develops a crush on him and announces she will spend two days working at the shop where she surprisingly becomes friends with Noela, despite their disagreements and Elaine's superiority complex.

"Sweetheart Cooling Gel": During hot weather Elaine’s father, Lord Valgas, asks Reiji to create a potion that will bring winter. Despite his irritation at the assumption he uses magic instead of medicine, Reiji creates Sweetheart Cooling Gel which evaporates quickly and rapidly cools the body when applied to skin, though the girls use too much and begin freezing despite the hot weather.

"Rokushou Sauce":Reiji treats a sick squirrel, causing the squirrel to bring nuts to the store in gratitude. Reiji overhears waitress Rena and her father arguing with a noble named Fernando who wants to buy their tavern Rabbit Tavern to stop them competing with his restaurant. They realise the nuts are Rokushou nuts, a high quality ingredient that is difficult to find and to cook but results in a sauce suitable for royalty. Reiji uses his chemistry knowledge to recreate Rokushou Sauce according to the recipe. Fernando is furious the sauce is being served in a common tavern and demands Reiji sell him his entire stock, but Reiji refuses as he made the sauce for the tavern and Fernando is defeated.

"Emotional Drive":Feris visits and explains she wants a baby with Zeral, but recently they have been having less sex so she wants an aphrodisiac to increase Zeral’s desire. After speaking to Zeral and realising Zeral wants to marry Feris Reiji decides the aphrodisiac will probably be harmless, but Mina accidentally drinks it. While trying to evade Mina’s erotic demands Reiji can’t stop Noela giving the aphrodisiac to Annabelle. Reiji is able to give them both an antidote before anything drastic happens and eventually gives the aphrodisiac to Zeral, making Feris very happy.

"Come Here Beast Lure":The Kalta hunting competition approaches. Ririka, an elf, wants to impress her brother Kururu who is the current champion, despite being a very poor archer. After giving her a potion to soothe her injured hands Reiji advises she use a short bow and brews a medicinal lure that attracts animals. Using this Ririka easily wins and beats Kururu’s record with 86 kills, again 19 of her brother's. Deciding to thank Reiji she rushes to his store but becomes jealous when she sees Noela and Mina and realises she has fallen in love with Reiji. Kururu later on goes to the store and personally thanks him, but there is a catch.

"Mother's Brooch":Mina is upset she cannot go outside and reappears in the living room if she tries. Reiji discovers a cellar under the living room with the help of the resident carpenter and finds a brooch that belonged to Mina’s mother. They discover Mina is actually tied to the brooch, not the store, so by keeping the brooch in her pocket she can finally go outside.

"Stomach Acheless":Noela gets a stomach ache eating nuts off the floor. Mina wonders if it has become habit to eat nuts since the squirrel keeps bringing them. Reiji brews medicine that makes food taste bitter so Noela stops eating food off the floor. Reiji later sells his medicine to shop owners to stop animals eating from their bins.

"Stuck-In-Place Super Glue":Noela breaks Mina’s kitchen knife. Paula, the tool seller, is exhausted as she has hundreds of items to repair. Her latest project is Annabelle’s broken gauntlets that resist all attempts at repair and she angrily wishes a liquid existed that could stick broken things together. Reiji invents Stuck-In-Place-Super-Glue which Paula uses to make repairs much faster. Unfortunately Noela gets glue on her hands and ends up stuck to Reiji. To avoid having to shower or sleep together Reiji invents Stuck-No-More-Releasing-Agent to melt the glue. Paula is able to go to bed on time and pays Reiji an exorbitant fee as thanks.

"Glossy Shine Polish":Paula complains that adventurers never buy anything from her shop. Reiji reveals her shop is so dark even her highest quality weapons look like rusty antiques. After cleaning her shop Reiji notices all Paula’s weapons and armour are dull and scratched, so he invents Glossy-Shine-Polish and Paula soon has all her merchandise gleaming and shiny. Unfortunately, adventurers do not often visit their village so she still doesn’t manage to sell anything. Elsewhere, it is revealed Demon King Ejil has become addicted to Reiji’s energy potion and when his servants are unable to bring him enough he decides to get more himself.

"Woof? Advent of the Demon King!":Ejil teleports to Reiji’s store and is outraged when Reiji expects payment. Ejil becomes smitten with Noela and offers Reiji half the planet, once he conquers it, in exchange for Noela and one potion but Reiji refuses. Ejil flees but returns with money extorted from villagers by claiming himself the Demon King. Reiji correctly guesses the villagers actually thought he was homeless. Reiji gives him one potion which Ejil tries to give to Noela, but she again rejects him as Reiji already gives her one potion a day. Humiliated, Ejil demands Reiji make him his apprentice and refuses to leave so Reiji agrees he can work as a weekend shop assistant.

"Give It to Me Straight":Ejil asks for a potion to read Noela’s thoughts and discover how she really feels about him. Reiji agrees in exchange for Ejil not destroying anything if Noela doesn’t like him. Reiji brews the potion Give-It-To-Me-Straight which broadcasts thoughts out loud. Ejil is disappointed Noela is totally indifferent about him, but remains determined to romance her. Mina accidentally drinks the potion, revealing her thoughts are dark and terrifying. Reiji decides never to sell the potion, afraid it would cause mass divorces throughout the country if drunk by married couples.

"Odorless Body Soap!":Lord Valgas is convinced Elaine is avoiding him and Reiji suspects it is puberty. Elaine reveals she doesn’t know why she dislikes her father. Reiji has a realisation and turns his deodorant into Odorless Body Soap for Valgas. After bathing and shaving his moustache Valgas attempts to speak to Elaine and eventually realises she does have a crush on Reiji and resented him for still treating her like a child. He promises to always support her and she forgives him. Valgas thanks Reiji but also reminds him he will never let Elaine marry him.

"Three-Minute Revive":Mina develops a fever and reveals she was always falling ill while alive but never got to thank her mother for taking care of her. Reiji sends Ejil to collect magical potion ingredients while he and Noela fetch Mina’s mother’s diary. Reiji explains the potion can summon Mina’s mother for three minutes. Mina uses the potion and summons the ghost of her mother’s emotions, revealing she resented Mina’s father for leaving her to care for Mina and was angry Mina was always sick but was sad when she died and regretted Mina never got to live a happy life. Mina is happy she got the chance to see her mother again and recovers from her fever.

"Big Catch Buddy":Reiji takes everyone on a picnic to a lake but find it is no longer visited by humans as monsters now live nearby. Reiji uses his potion, Big Catch Buddy, to lure fish and catches Vivi, the spirit of the lake. She explains she took Reiji’s bait because humans used to offer food at her shrine but since monsters appeared no one comes anymore and she is starving. As she can eat fish Reiji teaches her fishing and Vivi is surprised Reiji considers her a friend. To stop her being lonely Reiji offers her a part time job at his shop. She refuses as she must stay cold in her lake to hold her human shape, so Reiji uses his Sweetheart Cooling Gel to keep her cold and let her leave the lake.

"Harriette Remover":Paula and Annabelle visit with a feminine problem. Reiji brews them Harriette Remover, a cream that dissolves unwanted hair. Unfortunately Noela plays with the cream and the tip of her tail becomes completely bald. As the cream also prevents new hair growing back Reiji is forced to brew Harriette Grower that returns her tail to normal. Noela finally learns her lesson about playing with new potions.

"Power Potion":Vivi asks Reiji for a potion to make her stronger. A nearby Annabelle overhears and decides to put Vivi, Noela and Mina through soldier training with Noela even forcing Reiji to join in. As no one except Noela is fit enough to meet Annabelle’s standards Reiji alters his original energy potion and creates “Power Potion” which aids muscle recovery after exercise, making building muscles more efficient. Unfortunately when drunk by Mina and Noela it instantly increases their muscle size and gives them professional bodybuilder personalities, but only for about an hour.

"RK Gene Fluid":Ejil has made no progress romancing Noela and demands a potion to fix it. As no such potion exists Reiji wondes if he can at least help them get along as colleagues in the shop. Noela explains she has an instinctive dislike of Ejil’s scent but likes Reiji’s a lot so Reiji brews “RK Gene Fluid” based on his scent for Ejil to add to his food and alter his scent chemically. After a week Noela cannot tell between the scents of Reiji and Ejil and while they do start getting along better she still dislikes Ejil because of his perverted behaviour.

"Pass, No Fail":Reiji becomes annoyed everyone only visits at mealtimes knowing Mina will feed them for free. Paula stops visiting and begins studying to renew her merchant’s license. Since she must close her shop if she fails she begs Reiji for a potion to make studying easier. Reiji agrees and brews a “Prayer for Success” potion to give Paula a perfect memory for 24 hours. A week later Paula learns she passed her exam and tries to kiss Reiji as thanks, but a jealous Noela stops her. With her success everyone returns to manipulating free food from Mina.

"Sun Sun Go Away Sunscreen Gel":Vivi notices a skin blemish so Reiji decides to add sunscreen protection and moisturisers to the Sweetheart Cooling Gel, which Mina is sure would be popular with young ladies and would help with their food bill which has inexplicably become highly expensive. Reiji successfully makes “Sun Sun Go Away Sunscreen Gel” which protects against sunburn and makes the girls skin springy and bouncier which has a severe nosebleed effect on Ejil when he sees Noela’s newly moisturised skin. Word spreads quickly and every female customer Reiji has ever had buys his entire supply.

"Let's Open a Drugstore in Another World!":Elaine invites everyone to a party. Reiji is uncomfortable as he never enjoyed parties with his co-workers in Japan. Doz is worried he cannot handle alcohol and doesn’t want to embarrass himself. Reiji creates Liver Buddy EX to temporarily prevent drunkenness and hangovers. Mina finds her old party dresses are disintegrating, so Reiji brews Dress Cleaner to restore damaged fabric. Ejil’s butler tries to locate Ejil. Reiji tries on his suit but the necktie reminds him of wearing ties to work. When the butler sees Reiji is capable of controlling Ejil he returns home. Reiji has a nap and dreams of how one moment he was a miserable salaryman, the next he woke up in the new world with the ability to create potions. He immediately treated an injured wolf who transformed into Noela. Waking, everyone travels to the party, except Ejil who missed the carriage. At the party Reiji realises his potions have made him popular among young noble ladies who compete for his attention. Zeral is caught flirting by Feris who tries to kill him. Ejil realises that due to being late the party gates are closed and he cannot get in. Reiji realises he actually enjoys parties while dancing with Noela and Mina.