Dynorphin A[1]
Other names
Dynorphin 1-13
Molar mass 1603.95474
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dynorphin A is a dynorphin, an endogenous opioid peptide with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

Dynorphin A1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.[2][3] Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;[3] it has the highest binding affinity for the kappa-opioid receptor.[3]


  1. ^ Dynorphin 1-13 - Compound Summary, PubChem.
  2. ^ "Dynorphin A 1-8". HMDB Version 4.0. Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017.
  3. ^ a b c "Dynorphin A-(1-8): Biological activity". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 20 October 2017. Principal endogenous agonists at κ receptor