E2F4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CF7
Identifiers
Aliases	E2F4, E2F-4, E2F transcription factor 4
External IDs	OMIM: 600659 MGI: 103012 HomoloGene: 1471 GeneCards: E2F4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,192,155 bp[1] End 67,198,918 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,024,295 bp[2] End 106,032,002 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell left uterine tube anterior pituitary transverse colon body of stomach right lobe of thyroid gland upper lobe of left lung left lobe of thyroid gland monocyte rectum Top expressed in yolk sac lip secondary oocyte morula interventricular septum superior frontal gyrus thymus neural tube spermatocyte pharynx More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein domain specific binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding promoter-specific chromatin binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding Cellular component transcription regulator complex nucleoplasm nucleus RNA polymerase II transcription regulator complex Biological process regulation of cell size epithelial cell development cell volume homeostasis regulation of transcription, DNA-templated multi-ciliated epithelial cell differentiation transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle blood circulation cell projection organization regulation of cell population proliferation animal organ morphogenesis cell cycle motile cilium assembly centriole assembly transcription, DNA-templated mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of transcription by RNA polymerase II cilium assembly negative regulation of transcription by RNA polymerase II regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1874 104394 Ensembl ENSG00000205250 ENSMUSG00000014859 UniProt Q16254 Q8R0K9 RefSeq (mRNA) NM_001950 NM_148952 RefSeq (protein) NP_001941 NP_683754 Location (UCSC) Chr 16: 67.19 – 67.2 Mb Chr 8: 106.02 – 106.03 Mb PubMed search [3] [4]
Wikidata
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Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.^[5][6]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.^[7]

Structure

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.

Interactions

E2F4 has been shown to interact with Smad3.^[8]