E2F5
Identifiers
Aliases	E2F5, E2F-5, E2F transcription factor 5
External IDs	OMIM: 600967 MGI: 105091 HomoloGene: 1472 GeneCards: E2F5
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.2 Start 85,177,154 bp[1] End 85,217,158 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 14,643,701 bp[2] End 14,671,369 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence lymph node islet of Langerhans rectum appendix tibial nerve right uterine tube anterior pituitary right adrenal gland left adrenal gland Top expressed in secondary oocyte somite abdominal wall primitive streak medial ganglionic eminence submandibular gland proximal tubule maxillary prominence ovary atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding Cellular component cytoplasm nucleolus nucleus transcription regulator complex nucleoplasm fibrillar center RNA polymerase II transcription regulator complex Biological process animal organ morphogenesis regulation of cell cycle cell projection organization regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1875 13559 Ensembl ENSG00000133740 ENSMUSG00000027552 UniProt Q15329 Q61502 RefSeq (mRNA) NM_001083588 NM_001083589 NM_001951 NM_007892 RefSeq (protein) NP_001077057 NP_001077058 NP_001942 NP_031918 Location (UCSC) Chr 8: 85.18 – 85.22 Mb Chr 3: 14.64 – 14.67 Mb PubMed search [3] [4]
Wikidata
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Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.^[5][6]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.^[6]

Interactions

E2F5 has been shown to interact with TFDP1.^[5][7]