EBF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDsOMIM: 164343 MGI: 95275 HomoloGene: 7297 GeneCards: EBF1
Orthologs
SpeciesHumanMouse
Entrez

1879

13591

Ensembl

ENSG00000164330

ENSMUSG00000057098

UniProt

Q9UH73

Q07802

RefSeq (mRNA)

NM_001290709
NM_001290710
NM_001290711
NM_007897

RefSeq (protein)
Location (UCSC)Chr 5: 158.7 – 159.1 MbChr 11: 44.62 – 45.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.[5][6][7]

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[8][9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[10] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.[11]

Interactions

EBF1 has been shown to interact with ZNF423[12] and CREB binding protein.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164330 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057098 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
  6. ^ Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110. S2CID 19839522.
  7. ^ "Entrez Gene: EBF1 early B-cell factor 1".
  8. ^ Treiber, Thomas; Mandel, Elizabeth M.; Pott, Sebastian; Györy, Ildiko; Firner, Sonja; Liu, Edison T.; Grosschedl, Rudolf (2010). "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. PMID 20451411.
  9. ^ Hagman, James; Ramírez, Julita; Lukin, Kara (2012-01-01). "B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1". Current Topics in Microbiology and Immunology. 356: 17–38. doi:10.1007/82_2011_139. ISBN 978-3-642-24102-4. ISSN 0070-217X. PMC 3925327. PMID 21735360.
  10. ^ Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
  11. ^ Takács, Roland; Vágó, Judit; Póliska, Szilárd; Pushparaj, Peter Natesan; Ducza, László; Kovács, Patrik; Jin, Eun-Jung; Barrett-Jolley, Richard; Zákány, Róza; Matta, Csaba (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.
  12. ^ Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi:10.1523/JNEUROSCI.17-11-04159.1997. PMC 6573535. PMID 9151733.
  13. ^ Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Further reading

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