EDEM1
Identifiers
Aliases	EDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDs	OMIM: 607673 MGI: 2180139 HomoloGene: 33836 GeneCards: EDEM1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.1 Start 5,187,646 bp[1] End 5,219,958 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E2 Start 108,805,602 bp[2] End 108,836,317 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells thymus liver right lobe of liver lymph node appendix thymus stromal cell of endometrium monocyte spongy bone Top expressed in lacrimal gland thymus parotid gland crypt of lieberkuhn of small intestine left lobe of liver submandibular gland islet of Langerhans seminal vesicula jejunum pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding misfolded protein binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity protein binding catalytic activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum quality control compartment Golgi membrane aggresome Biological process N-glycan processing positive regulation of retrograde protein transport, ER to cytosol trimming of terminal mannose on C branch IRE1-mediated unfolded protein response response to unfolded protein ubiquitin-dependent glycoprotein ERAD pathway mannose trimming involved in glycoprotein ERAD pathway ubiquitin-dependent ERAD pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9695 192193 Ensembl ENSG00000134109 ENSMUSG00000030104 UniProt Q92611 Q925U4 RefSeq (mRNA) NM_014674 NM_138677 RefSeq (protein) NP_055489 NP_619618 Location (UCSC) Chr 3: 5.19 – 5.22 Mb Chr 6: 108.81 – 108.84 Mb PubMed search [3] [4]
Wikidata
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ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.^[5][6]