EIF2AK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDsOMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001013703

NM_001177806
NM_013719
NM_001355383

RefSeq (protein)

NP_001013725

NP_001171277
NP_038747
NP_001342312

Location (UCSC)Chr 15: 39.93 – 40.04 MbChr 2: 118.22 – 118.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.[5][6]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
  6. ^ a b "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

Further reading