EIF4A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HXY, 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7, 4C9B
Identifiers
Aliases	EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, eIF4A-III, eIF-4A-III
External IDs	OMIM: 608546 MGI: 1923731 HomoloGene: 5602 GeneCards: EIF4A3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 80,134,369 bp[1] End 80,147,151 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,179,189 bp[2] End 119,190,915 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube olfactory bulb mucosa of urinary bladder skin of abdomen human penis left adrenal gland peritoneum right adrenal gland embryo ganglionic eminence Top expressed in morula neural tube thymus mesencephalon spleen bone marrow ganglionic eminence lung yolk sac placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding selenocysteine insertion sequence binding helicase activity poly(A) binding RNA stem-loop binding protein binding nucleic acid binding ribonucleoprotein complex binding hydrolase activity ATP binding mRNA binding RNA binding translation regulator activity Cellular component cytoplasm cytosol nuclear speck catalytic step 2 spliceosome membrane exon-exon junction complex neuronal cell body dendrite spliceosomal complex nucleus nucleoplasm nucleolus glutamatergic synapse postsynaptic cytosol ribonucleoprotein complex U2-type catalytic step 1 spliceosome Biological process nuclear-transcribed mRNA poly(A) tail shortening mRNA transport negative regulation of translation associative learning response to organic cyclic compound regulation of mRNA binding mRNA processing positive regulation of translation negative regulation of gene expression negative regulation of excitatory postsynaptic potential cellular response to brain-derived neurotrophic factor stimulus cellular response to selenite ion exploration behavior RNA secondary structure unwinding RNA splicing rRNA processing embryonic cranial skeleton morphogenesis negative regulation of selenocysteine insertion sequence binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translation negative regulation of selenocysteine incorporation mRNA splicing, via spliceosome RNA export from nucleus termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing positive regulation of transcription by RNA polymerase II positive regulation of mRNA splicing, via spliceosome transport regulation of translation at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9775 192170 Ensembl ENSG00000141543 ENSMUSG00000025580 UniProt P38919 Q91VC3 RefSeq (mRNA) NM_014740 NM_138669 RefSeq (protein) NP_055555 NP_619610 Location (UCSC) Chr 17: 80.13 – 80.15 Mb Chr 11: 119.18 – 119.19 Mb PubMed search [3] [4]
Wikidata
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Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.^[5][6][7]

Function

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.^[7]