EIF4EBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4EBP2, 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
External IDsOMIM: 602224 MGI: 109198 HomoloGene: 3022 GeneCards: EIF4EBP2
Orthologs
SpeciesHumanMouse
Entrez

1979

13688

Ensembl

ENSG00000148730

ENSMUSG00000020091

UniProt

Q13542

P70445

RefSeq (mRNA)

NM_004096

NM_010124

RefSeq (protein)

NP_004087
NP_004087.1

NP_034254

Location (UCSC)Chr 10: 70.4 – 70.43 MbChr 10: 61.26 – 61.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.[5][6][7]

Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.[8]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.[5][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148730 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020091 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N (October 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–7. Bibcode:1994Natur.371..762P. doi:10.1038/371762a0. PMID 7935836. S2CID 4360955.
  6. ^ Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H, Sonenberg N (December 1996). "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics. 38 (3): 353–63. doi:10.1006/geno.1996.0638. PMID 8975712.
  7. ^ "Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2".
  8. ^ Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N (January 2013). "Autism-related deficits via dysregulated eIF4E-dependent translational control". Nature. 493 (7432): 371–7. Bibcode:2013Natur.493..371G. doi:10.1038/nature11628. PMC 4133997. PMID 23172145.
  9. ^ Mader S, Lee H, Pause A, Sonenberg N (September 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology. 15 (9): 4990–7. doi:10.1128/mcb.15.9.4990. PMC 230746. PMID 7651417.

Further reading


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