ENC1
Identifiers
Aliases	ENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10, ectodermal-neural cortex 1
External IDs	OMIM: 605173 MGI: 109610 HomoloGene: 2694 GeneCards: ENC1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 74,627,406 bp[1] End 74,641,424 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 97,241,105 bp[2] End 97,253,034 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole middle temporal gyrus ganglionic eminence orbitofrontal cortex Brodmann area 46 superior frontal gyrus Region I of hippocampus proper parietal lobe postcentral gyrus Top expressed in barrel cortex medial ganglionic eminence subiculum olfactory tubercle prefrontal cortex nucleus accumbens medial dorsal nucleus medial geniculate nucleus ventromedial nucleus superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm nuclear matrix neuronal cell body Cul3-RING ubiquitin ligase complex nucleolus cytoskeleton nucleus nucleoplasm Biological process multicellular organism development negative regulation of translation proteasomal ubiquitin-independent protein catabolic process protein ubiquitination nervous system development positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8507 13803 Ensembl ENSG00000171617 ENSMUSG00000041773 UniProt O14682 O35709 RefSeq (mRNA) NM_001256574 NM_001256575 NM_001256576 NM_003633 NM_007930 RefSeq (protein) NP_001243503 NP_001243504 NP_001243505 NP_003624 NP_031956 Location (UCSC) Chr 5: 74.63 – 74.64 Mb Chr 13: 97.24 – 97.25 Mb PubMed search [3] [4]
Wikidata
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Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.^[5][6][7]

Function

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]^[7]

Interactions

ENC1 has been shown to interact with Retinoblastoma protein.^[6]