EPHA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs	OMIM: 176945 MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 22,563,489 bp[1] End 22,603,595 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 136,929,419 bp[2] End 136,956,816 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus superior frontal gyrus occipital lobe Top expressed in cerebellar cortex visual cortex superior frontal gyrus entorhinal cortex lens superior colliculus habenula neuron pretectal area basal forebrain More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity GPI-linked ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane endosome cell projection early endosome membrane membrane integral component of plasma membrane plasma membrane neuron projection cytoplasm receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development multicellular organism development protein phosphorylation cell adhesion peptidyl-tyrosine phosphorylation substrate-dependent cell migration protein autophosphorylation axon guidance neuron projection development regulation of cell adhesion regulation of cell adhesion mediated by integrin neuron remodeling positive regulation of phosphatidylinositol 3-kinase activity ephrin receptor signaling pathway positive regulation of MAPK cascade cellular response to follicle-stimulating hormone stimulus negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2046 13842 Ensembl ENSG00000070886 ENSMUSG00000028661 UniProt P29322 O09127 RefSeq (mRNA) NM_001006943 NM_020526 NM_007939 RefSeq (protein) NP_001006944 NP_065387 NP_031965 Location (UCSC) Chr 1: 22.56 – 22.6 Mb Chr 4: 136.93 – 136.96 Mb PubMed search [3] [4]
Wikidata
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Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.^[5][6]

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.^[6]

Interactions

EPHA8 has been shown to interact with FYN.^[7]