ERRFI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RF9, 2RFD, 2RFE, 4I21, 4R3P, 4R3R, 4ZJV
Identifiers
Aliases	ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs	OMIM: 608069 MGI: 1921405 HomoloGene: 10344 GeneCards: ERRFI1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 8,004,404 bp[1] End 8,026,309 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 150,938,376 bp[2] End 150,953,349 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas vena cava right lobe of liver tibialis anterior muscle gastric mucosa synovial joint ascending aorta synovial membrane pancreatic epithelial cell left uterine tube Top expressed in left lobe of liver gallbladder kidney right lung lobe left lung left lung lobe carotid body secondary oocyte utricle medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity SH3 domain binding kinase binding protein binding protein kinase binding small GTPase binding Cellular component membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane nucleus cytoplasm cytosol Biological process negative regulation of interleukin-1 beta production negative regulation of epidermal growth factor receptor signaling pathway skin morphogenesis negative regulation of protein autophosphorylation cellular response to platelet-derived growth factor stimulus cellular response to dexamethasone stimulus cellular response to epidermal growth factor stimulus cellular hyperosmotic response negative regulation of epidermal growth factor-activated receptor activity negative regulation of peptidyl-tyrosine phosphorylation cellular response to insulin stimulus negative regulation of ERK1 and ERK2 cascade regulation of keratinocyte differentiation lung alveolus development lung vasculature development lung epithelium development regulation of type B pancreatic cell proliferation negative regulation of collagen biosynthetic process negative regulation of cardiac muscle hypertrophy in response to stress positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54206 74155 Ensembl ENSG00000116285 ENSMUSG00000028967 UniProt Q9UJM3 Q99JZ7 RefSeq (mRNA) NM_018948 NM_133753 NM_001356323 RefSeq (protein) NP_061821 NP_598514 NP_001343252 Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.94 – 150.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.^{[5][6][7][8][9]}

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).^[9]

Interactions

ERRFI1 has been shown to interact with Stratifin^[10] and CDC42.^[5]