Geography

Eastern world, the region comprising Asia and the Middle East
Far East, the region comprising East Asia and Southeast Asia
Eastern Bloc, the Soviet Union and other states in the Warsaw Pact during the Cold War
The Orient, an early-modern term for lands east of Western Europe.
Eastern Europe, the region between the Ural Mountains(along with the Ural River), and Central Europe, although the cutoff line westward is not well defined.
Eastern Asia, the region generally defined as comprising China, Japan, the Koreas, and Taiwan, sometimes including Southeast Asia(making the term sometimes synonymous with the "Far East", depending on the context).

East (Cornish hundred), a division of the UK country of England
East (European Parliament constituency), a constituency in the Republic of Ireland
East, West Virginia, an unincorporated community in the United States
East Coast of the United States, the easternmost coast of the United States along the Atlantic Ocean
- Eastern United States, a term often describing the U.S. states east of the Mississippi River
Eastern Roman Empire, the predominantly Greek-speaking continuation of the Roman Empire during Late Antiquity and the Middle Ages

Acronyms

Experimental Advanced Superconducting Tokamak, a nuclear fusion experiment facility in China

European Association for Solar Telescopes, a consortium for the development of the European Solar Telescope
East Asia School of Theology, in Singapore
Eastern Association for the Surgery of Trauma, an American medical association

East African Standard Time (EAST) and timezone, see East Africa Time (EAT)
Easter Island Standard Time and timezone, UTC−6:00 with UTC−5:00 at daylight saving time