End-systolic volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
ESV is the lowest volume of blood in the ventricle at any point in the cardiac cycle. The main factors that affect the end-systolic volume are afterload and the contractility of the heart.
End systolic volume can be used clinically as a measurement of the adequacy of cardiac emptying, related to systolic function. On an electrocardiogram, or ECG, the end-systolic volume will be seen at the end of the T wave. Clinically, ESV can be measured using two-dimensional echocardiography, MRI (magnetic resonance tomography) or cardiac CT (computed tomography) or SPECT (single photon emission computed tomography).
Along with end-diastolic volume, ESV determines the stroke volume, or output of blood by the heart during a single phase of the cardiac cycle. The stroke volume is the difference between the end-diastolic volume and the end-systolic volume. The end-systolic values in the table below are for the left ventricle:
|Measure||Right ventricle||Left ventricle|
|End-diastolic volume||144 mL (± 23 mL)||142 mL (± 21 mL)|
|End-diastolic volume / body surface area (mL/m2)||78 mL/m2 (± 11 mL/m2)||78 mL/m2 (± 8.8 mL/m2)|
|End-systolic volume||50 mL (± 14 mL)||47 mL (± 10 mL)|
|End-systolic volume / body surface area (mL/m2)||27 mL/m2 (± 7 mL/m2)||26 mL/m2 (± 5.1 mL/m2)|
|Stroke volume||94 mL (± 15 mL)||95 mL (± 14 mL)|
|Stroke volume / body surface area (mL/m2)||51 mL/m2 (± 7 mL/m2)||52 mL/m2 (± 6.2 mL/m2)|
|Ejection fraction||66% (± 6%)||67% (± 4.6%)|
|Heart rate||60–100 bpm||60–100 bpm|
|Cardiac output||4.0–8.0 L/minute||4.0–8.0 L/minute|
The right ventricular end-systolic volume (RVESV) normally ranges between 50 and 100 mL.