EFNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HLE, 2I85, 2VSK, 2VSM, 2WO2, 3GXU, 4UF7
Identifiers
Aliases	EFNB2, EPLG5, HTKL, Htk-L, LERK5, ephrin B2
External IDs	OMIM: 600527 MGI: 105097 HomoloGene: 3019 GeneCards: EFNB2
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q33.3 Start 106,489,745 bp[1] End 106,535,662 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 3.42 cM Start 8,667,434 bp[2] End 8,711,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence visceral pleura amniotic fluid parietal pleura periodontal fiber secondary oocyte nipple hair follicle endothelial cell metanephric glomerulus Top expressed in medullary collecting duct renal corpuscle hair follicle right lung left lung ganglionic eminence vas deferens right lung lobe belly cord left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity protein binding signaling receptor binding ephrin receptor binding protein tyrosine kinase activity Cellular component integral component of membrane membrane focal adhesion plasma membrane integral component of plasma membrane Schaffer collateral - CA1 synapse glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane Biological process cell differentiation blood vessel morphogenesis negative regulation of keratinocyte proliferation regulation of chemotaxis cell-cell signaling anatomical structure morphogenesis T cell costimulation lymph vessel development nervous system development cell migration involved in sprouting angiogenesis multicellular organism development cell adhesion nephric duct morphogenesis angiogenesis animal organ morphogenesis viral entry into host cell positive regulation of cardiac muscle cell differentiation viral process venous blood vessel morphogenesis positive regulation of aorta morphogenesis positive regulation of cell population proliferation ephrin receptor signaling pathway axon guidance negative regulation of neuron projection development peptidyl-tyrosine phosphorylation presynapse assembly regulation of postsynaptic membrane neurotransmitter receptor levels regulation of postsynaptic neurotransmitter receptor internalization positive regulation of neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1948 13642 Ensembl ENSG00000125266 ENSMUSG00000001300 UniProt P52799 P52800 RefSeq (mRNA) NM_004093 NM_001372056 NM_001372057 NM_001372058 NM_010111 NM_001368299 RefSeq (protein) NP_004084 NP_001358985 NP_001358986 NP_001358987 NP_034241 NP_001355228 Location (UCSC) Chr 13: 106.49 – 106.54 Mb Chr 8: 8.67 – 8.71 Mb PubMed search [3] [4]
Wikidata
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Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.^[5]

Function

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.^[6]

Cancer

EFNB2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[7] For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[7]

Interactions

EFNB2 has been shown to interact with EPHA3^[8][9] and EPHB1 in optic chiasm development.^[10]

EFNB2 has also been shown to serve as a receptor for Hendra Virus and Nipah Virus, mediating entry into the cell during infection.^[11]