Erysipelas
Other namesIgnis sacer, holy fire, St. Anthony's fire
Erysipelas of the face due to invasive Streptococcus
Pronunciation
SpecialtyDermatology, Infectious disease

Erysipelas is a relatively common bacterial infection of the superficial layer of the skin (upper dermis), extending to the superficial lymphatic vessels within the skin, characterized by a raised, well-defined, tender, bright red rash, typically on the face or legs, but which can occur anywhere on the skin. It is a form of cellulitis and is potentially serious.[1][2][3]

Erysipelas is usually caused by the bacteria Streptococcus pyogenes, also known as group A β-hemolytic streptococci, through a break in the skin such as from scratches or an insect bite. It is more superficial than cellulitis, and is typically more raised and demarcated.[4] The term is from Greek ἐρυσίπελας (erysípelas), meaning "red skin".[5]

In animals, erysipelas is a disease caused by infection with the bacterium Erysipelothrix rhusiopathiae. The disease caused in animals is called Diamond Skin Disease, which occurs especially in pigs. Heart valves and skin are affected. Erysipelothrix rhusiopathiae can also infect humans, but in that case the infection is known as erysipeloid.[citation needed]

Signs and symptoms

Symptoms often occur suddenly. Affected individuals may develop a fever, shivering, chills, fatigue, headaches, vomiting and be generally unwell within 48 hours of the initial infection.[1][2] The red plaque enlarges rapidly and has a sharply demarcated, raised edge.[4][6] It may appear swollen, feel firm, warm and tender to touch and may have a consistency similar to orange peel.[2] Pain may be extreme.[6]

More severe infections can result in vesicles (pox or insect bite-like marks), blisters, and petechiae (small purple or red spots), with possible skin necrosis (death).[6] Lymph nodes may be swollen, and lymphedema may occur. Occasionally, a red streak extending to the lymph node can be seen.[citation needed]

The infection may occur on any part of the skin, including the face, arms, fingers, legs and toes; it tends to favour the extremities.[1] The umbilical stump and sites of lymphoedema are also common sites affected.[6]

Fat tissue and facial areas, typically around the eyes, ears, and cheeks, are most susceptible to infection.[citation needed] Repeated infection of the extremities can lead to chronic swelling (lymphoedema).[2]

Cause

Streptococcus pyogenes
Streptococcus pyogenes

Most cases of erysipelas are due to Streptococcus pyogenes, also known as group A β-hemolytic streptococci, less commonly by group C or G streptococci and rarely due to Staphylococcus aureus. Newborns may contract erysipelas due to Streptococcus agalactiae, also known as group B streptococcus or GBS.[6]

The infecting bacteria can enter the skin through minor trauma, human, insect or animal bites, surgical incisions, ulcers, burns and abrasions. There may be underlying eczema, athlete's foot, and it can originate from streptococci bacteria in the subject's own nasal passages or ear.[6]

The rash is due to an exotoxin, not the Streptococcus bacteria, and is found in areas where no symptoms are present; e.g., the infection may be in the nasopharynx, but the rash is found usually on the epidermis and superficial lymphatics.[citation needed]

Diagnosis

Erysipelas is usually diagnosed by the clinician looking at the characteristic well-demarcated rash following a history of injury or recognition of one of the risk factors.[2]

Tests, if performed, may show a high white cell count, raised CRP or positive blood culture identifying the organism.[2]

Erysipelas must be differentiated from herpes zoster, angioedema, contact dermatitis, erythema chronicum migrans of early Lyme disease, gout, septic arthritis, septic bursitis, vasculitis, allergic reaction to an insect bite, acute drug reaction, deep venous thrombosis and diffuse inflammatory carcinoma of the breast.[citation needed]

Differentiating from cellulitis

Erysipelas can be distinguished from cellulitis by two particular features;its raised advancing edge and its sharp borders. The redness in cellulitis is not raised and its border is relatively indistinct.[6] Bright redness of erysipelas has been described as a third differentiating feature.[7]

Erysipelas does not affect subcutaneous tissue. It does not release pus, only serum or serous fluid. Subcutaneous edema may lead the physician to misdiagnose it as cellulitis.[8][clarification needed]

Treatment

Depending on the severity, treatment involves either oral or intravenous antibiotics, using penicillins, clindamycin, or erythromycin. While illness symptoms resolve in a day or two, the skin may take weeks to return to normal. The FDA approved 3 antibiotics, oritavancin (Orbactiv), dalbavancin (Dalvance), and tedizolid (Sivextro), for the treatment of acute bacterial skin and skin structure infections. Because of the risk of reinfection, prophylactic antibiotics are sometimes used after resolution of the initial condition.[2]

Prognosis

The disease prognosis includes:

Epidemiology

There is currently no validated recent data on the worldwide incidence of erysipelas.[11] From 2004-2005, UK hospitals reported 69,576 cases of cellulitis and 516 cases of Erysipelas.[11] One book stated that several studies have placed the prevalence rate between every one in 10,000 people and every 250 in 10,000 people.[12] The development of antibiotics, as well as increased sanitation standards has contributed to the decreased rate of incidence.[13] Erysipelas caused systemic illness in up to 40% of cases reported by UK hospitals and 29% of people had recurrent episodes within three years.[11] Anyone can be infected, although incidence rates are higher in infants and elderly.[13] Several studies also reported a higher incidence rate in females.[13] Four out of five cases occur on the legs, although historically the face was a more frequent site.[3]

Risk factors for developing the disease include [12][11][13][14]

Preventative Measures

Individuals can take preventative steps to increase the chance they do not catch the disease. Properly cleaning and covering wounds is important for people battling an open wound. Effectively treating athlete's foot or eczema if they were the cause for the initial infection will decrease the chance of the infection occurring again. People with diabetes should pay attention to maintaining good foot hygiene.[12] It is also important to follow up with doctors to make sure the disease has not come back or spread. About one third of people who have had erysipelas will be infected again within three years.[11] Rigorous antibiotics may be needed in the case of recurrent bacterial skin infections.[12]

Notable cases

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Fatal, in order of death

Chronic, recurrent

Recovered

Fictional

History

It was historically known as St. Anthony's fire.[3]

Citations

  1. ^ a b c O'Brian, Gail M. (2019). "Section 1. Diseases and Disorders; Erysipelas". In Fred F. Ferri (ed.). Ferri's Clinical Advisor 2019: 5 Books in 1. Philadelphia: Elsevier. p. 523. ISBN 978-0-323-53042-2.
  2. ^ a b c d e f g Stanway, Amy; Oakley, Amanda; Gomez, Jannet (2016). "Erysipelas | DermNet NZ". dermnetnz.org. Retrieved 6 June 2020.
  3. ^ a b c Davis, Loretta S. (9 November 2019). "Erysipelas: Background, Pathophysiology and Etiology, Epidemiology". Medscape.
  4. ^ a b Wanat, Karolyn A.; Norton, Scott A. "Skin & Soft Tissue Infections - Chapter 11 - 2020 Yellow Book | Travelers' Health | CDC". wwwnc.cdc.gov. CDC. Retrieved 6 June 2020.
  5. ^ Bhat M, Sriram (2019). SRB's Clinical Methods in Surgery. New Delhi: Jaypee Brothers Medical Publishers. p. 141. ISBN 978-93-5270-545-0.
  6. ^ a b c d e f g Wolff, Klaus; Johnson, Richard (2009). "Part III; Diseases due to microbial agents". Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology: Sixth Edition. McGraw Hill Professional. p. 609. ISBN 978-0-07-163342-0.
  7. ^ Stevens, Dennis L.; Bryant, Amy E. (2016), Ferretti, Joseph J.; Stevens, Dennis L.; Fischetti, Vincent A. (eds.), "Impetigo, Erysipelas and Cellulitis", Streptococcus pyogenes: Basic Biology to Clinical Manifestations, University of Oklahoma Health Sciences Center, PMID 26866211, retrieved 8 June 2020
  8. ^ Spelman, Denis. "Cellulitis and skin abscess: Clinical manifestations and diagnosis". UpToDate. UpToDate. Retrieved 30 July 2019.
  9. ^ Jorup-Rönström, Christina; Britton, S. (1987-03-01). "Recurrent erysipelas: Predisposing factors and costs of prophylaxis". Infection. 15 (2): 105–106. doi:10.1007/BF01650206. ISSN 0300-8126. PMID 3110071. S2CID 29789051.
  10. ^ Nigar Kirmani; Keith F. Woeltje; Hilary Babcock (2012). The Washington Manual of Infectious Disease Subspecialty Consult. Lippincott Williams & Wilkins. ISBN 9781451113648. Page 194
  11. ^ a b c d e Morris, Andrew D (2008-01-02). "Cellulitis and erysipelas". BMJ Clinical Evidence. 2008. ISSN 1752-8526. PMC 2907977. PMID 19450336.
  12. ^ a b c d Information, National Center for Biotechnology; Pike, U. S. National Library of Medicine 8600 Rockville; MD, Bethesda; Usa, 20894 (2018-02-22). Erysipelas and cellulitis: Overview. Institute for Quality and Efficiency in Health Care (IQWiG).CS1 maint: numeric names: authors list (link)
  13. ^ a b c d Michael, Youstina; Shaukat, Nadia M. (2020), "Erysipelas", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30335280, retrieved 2020-11-13
  14. ^ "Erysipelas | DermNet NZ". dermnetnz.org. Retrieved 2020-11-30.
  15. ^ "Throckmorton, Margaret [name in religion Magdalen] (1591–1668), prioress of St Monica's, Louvain". Oxford Dictionary of National Biography. doi:10.1093/ref:odnb/106107. Retrieved 2021-01-31.
  16. ^ "Berkeley, Norborne, baron de Botetourt (1717–1770)".
  17. ^ Dennis Butts, "Hofland, Barbara (bap. 1770, d. 1844)", Oxford Dictionary of National Biography (Oxford, UK: OUP, 2004 Retrieved 20 December 2015, pay-walled.
  18. ^ Green, Elizabeth Alden (1979). Mary Lyon and Mount Holyoke. Hanover, New Hampshire: University Press of New England. p. 310. ISBN 978-0-87451-172-7.
  19. ^ Møller, Jan (1994). Frederik 7. En kongeskæbne. Copenhagen: Aschehoug Dansk Forlag. p. 235. ISBN 978-87-11-22878-4.
  20. ^ Castillo, Dennis (2017-04-14). "Viewpoints: Remembering Buffalo's first Catholic bishop, John Timon, 'a great and good man'". The Buffalo News. Retrieved 2017-04-17.
  21. ^ Capaldi, Nicholas (2004). John Stuart Mill: a biography. Cambridge, UK: Cambridge University Press. pp. 356. ISBN 978-0-521-62024-6.
  22. ^ Australian Variety Theatre Archive • http://ozvta.com/practitioners-other-a-l/
  23. ^ Ridley, Jane (2013). The Heir Apparent: a life of Edward VII, the Crown Prince. New York, NY: Penguin Random House LLC. p. 287.
  24. ^ America the Beautiful by Lynn Sherr
  25. ^ Macy, Beth. Truevine. Little, Brown & Co, New York, 2016, page 151.
  26. ^ Trachtenberg, Leo (1995). The Wonder Team: The True Story of the Incomparable 1927 New York Yankees. Bowling Green State University Popular Press. p. 151. ISBN 0-87972-677-6.
  27. ^ Wollenweber, Brother Leo (2002). "Meet Solanus Casey". St. Anthony Messenger Press, Cincinnati, Ohio, page 107, ISBN 1-56955-281-9,
  28. ^ Rice, Christopher (1990). Lenin: Portrait of a Professional Revolutionary. London: Cassell. ISBN 978-0304318148. pp. 77–78.
  29. ^ Service, Robert (2000). Lenin: A Biography. London: Macmillan. ISBN 9780333726259. p. 150.
  30. ^ Rappaport, Helen (2010). Conspirator: Lenin in Exile. New York: Basic Books. ISBN 978-0-465-01395-1 pp. 85–87.
  31. ^ Hemingway, Mary Welsh (1976). How It Was. London: Weidenfeld & Nicolson. ISBN 0-297-77265-1. p. 236.
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