Estradiol hemisuccinate
Clinical data
Trade namesEutocol, Hosterona (with progesterone)
Other namesEstradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate
Routes of
administration		By mouth, intramuscular injection
Drug classEstrogen; Estrogen ester
Identifiers
  • 4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid
CAS Number
PubChem CID
PubChem SID
DrugBank
ChemSpider
UNII
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.163.857 Edit this at Wikidata
Chemical and physical data
FormulaC22H28O5
Molar mass372.461 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2OC(=O)CCC(=O)O)O
  • InChI=1S/C22H28O5/c1-22-11-10-16-15-5-3-14(23)12-13(15)2-4-17(16)18(22)6-7-19(22)27-21(26)9-8-20(24)25/h3,5,12,16-19,23H,2,4,6-11H2,1H3,(H,24,25)/t16-,17-,18+,19+,22+/m1/s1
  • Key:YJPIDPAGJSWWBE-FNIAAEIWSA-N

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol.[1] It is used as a component of hormone replacement therapy for menopause.[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.[2][3]

Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.[4][5][6]

See also

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.
  2. ^ a b Thompson Z, Maibach HI (2010). "Biological Effects of Estrogen on Skin". In Farage MA, Miller KW (eds.). Textbook of Aging Skin. pp. 361–367 (362). doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5.
  3. ^ Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (February 1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". American Journal of Obstetrics and Gynecology. 170 (2): 642–649. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.
  4. ^ "¿Qué es Hosterona y para qué sirve?" [What is Hosterona and what is it for?]. matchmyrx.com (in Spanish). PRX Control Solutions. Archived from the original on 13 April 2019.
  5. ^ "Hosterona - Para qué sirve" [Hosterona - What it is for]. Los Medicamentos (in Spanish). 23 November 2012.
  6. ^ "HOSTERONA (Hormonoterapia)". Laboratorio GADOR.
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