Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[5]
Function
The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[5]
According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.[8]
Role in pathology
FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[9]
As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[10] with one, that tested for only one SNP, showing negative[11] and another, with seven SNPs,[12] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.
Shi YE, Ni J, Xiao G, Liu YE, Fuchs A, Yu G, Su J, Cosgrove JM, Xing L, Zhang M, Li J, Aggarwal BB, Meager A, Gentz R (Aug 1997). "Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG". Cancer Research. 57 (15): 3084–91. PMID9242429.
Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T (Oct 1997). "Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1354 (1): 24–8. doi:10.1016/S0167-4781(97)00115-2. PMID9375786.
Rademacher M, Zimmerman AW, Rüterjans H, Veerkamp JH, Lücke C (Oct 2002). "Solution structure of fatty acid-binding protein from human brain". Molecular and Cellular Biochemistry. 239 (1–2): 61–8. doi:10.1023/A:1020566909213. PMID12479569. S2CID24296178.