FMNL1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4YDH
Identifiers
Aliases	FMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDs	OMIM: 604656 HomoloGene: 136798 GeneCards: FMNL1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,221,444 bp[1] End 45,247,319 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen right lung upper lobe of left lung lymph node bone marrow cells appendix gallbladder prefrontal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function profilin binding GTPase activating protein binding actin filament binding protein binding actin binding molecular function Cellular component cytoplasm cell projection membrane plasma membrane cell cortex phagocytic vesicle bleb extracellular exosome cytoplasmic vesicle cytosol integral component of membrane Biological process actin filament severing substrate-dependent cell migration cytoskeleton organization regulation of cell shape cellular component organization cortical actin cytoskeleton organization actin cytoskeleton organization cellular process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 752 n/a Ensembl ENSG00000184922 n/a UniProt O95466 n/a RefSeq (mRNA) NM_005892 n/a RefSeq (protein) NP_005883 n/a Location (UCSC) Chr 17: 45.22 – 45.25 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.^[3][4]

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.^[4]

Interactions

FMNL1 has been shown to interact with Profilin 1,^[5] PFN2^[5] and RAC1.^[5]