Facial features of a patient with familial dysautonomia over time: Note flattening of upper lip. By age 10, prominence of the lower jaw is apparent and by age 19 a mild erosion of right nostril occurs due to inadvertent self-mutilation.
FD results in variable symptoms, including insensitivity to pain, inability to produce tears, poor growth, and labile blood pressure (episodic hypertension and postural hypotension). People with FD have frequent vomiting crises, pneumonia, problems with speech and movement, difficulty swallowing, and inappropriate perception of heat, pain and taste, as well as unstable blood pressure and gastrointestinal dysmotility.
Originally reported by Drs. Conrad Milton Riley and Richard Lawrence Day in 1949,[4] FD is one example of a group of disorders known as hereditary sensory and autonomic neuropathies (HSANs).[5] All HSANs are characterized by widespread sensory dysfunction and variable autonomic dysfunction caused by incomplete development of sensory and autonomic neurons. The disorders are believed to be genetically distinct from each other.
Signs and symptoms
Signs and symptoms of familial dysautonomia usually commence during infancy and worsen with age, and may include gastrointestinal dysmotility (including erratic gastric emptying, gastroesophageal reflux, abnormal esophageal peristalsis, oropharyngeal incoordination),[3]dysphagia (as poor suckling in infancy) and frequent choking/gagging, recurrent vomiting, poor weight gain[6]/growth,[7] delayed development (especially walking) and puberty (especially in girls), recurrent aspiration pneumonia (due to inhalation of food or vomitus)[6] with possible secondary chronic lung disease,[3]absence of overflow tears during crying, corneal ulcers, red skin blotches and excessive sweating (often during eating or excitement), breath-holding spells, slurred speech/nasal voice, tongue ulcers (from accidental self-injuries), hyporeflexia (variable absence of deep tendon reflexes[8]), hypotonia, enuresis, arrhythmias, hypertension (including episodic hypertension in response to emotional stress or visceral pain[3]), hypotension (including orthostatic hypertension[7] with compensatory tachycardia (invariably present)[3]),[6] impaired (but not absent[3]) temperature and pain perception (leading to frequent accidental injury),[2][6] impaired proprioception, a smooth glossy tongue,[6] scoliosis (with possibly secondary restrictive lung disease[3]),[7] abnormal gait,[9] short stature, chronic renal failure (common), visual impairment, variable cognitive ability, characteristic facial features that develop with time, impaired vibration perception, lack of fungiform papilla of the tongue,[3] and impaired taste perception (especially for sweetness).[8]
Autonomic crises - In children with FD, recurrent episodes of vomiting may occur. Such episodes may be triggered by physical (e.g. infection) or emotional stress, may occur every 15–20 minutes for over 24 hours, and may be accompanied by significant hypertension, drenching sweat, breathing issues,[6] fever, tachycardia, aspiration pneumonia,[8] skin blotches, drooling, and negative personality change.[citation needed]
Pain insensitivity - Insensitivity or indifference to painful stimuli may lead to frequent/progressive self-mutilation, burns, and ulcers. There may be self-mutilation of the tongue (especially in toddlers during teething), lips, and cheeks, or loss of teeth. Compulsive oral biting may result in ulcers, or tumour-like masses (Riga-Fede disease).[8]
Progression
Familial dysautonomia presents with progressive,[3] age-specific symptoms.
Though usually not diagnosed until several years of age, generalised signs of FD are present during the newborn period in more than 80% of those affected.[8] Dysmorpnic facial features are not directly inherent to the disorder, but facial asymmetry and a straightened mouth eventually develop due to abnormal tone and molding of facial bones.[8][3]
Perinatal
A very high incidence of breech presentation has been noted among infants with FD.[8][10][11] A lower birth weight as compared to siblings,[10] premature birth, and intrauterine growth restriction[8] have also been noted.
Neonatal
During the neonatal period, hypotonia, respiratory insufficiency, poor feeding with difficulty swallowing and aspiration, developmental delay, short stature, scoliosis, and corneal disease may occur.[8]
Infancy
Issues related to the disorder first appear during infancy. Early manifestations include hypotonia, feeding difficulty (impaired swallowing and suckling[2]), poor growth, absence of tears, frequent lung infections, and poor body-temperature control (infants may display cold hands and feet[2]). Developmental milestones (e.g. walking, speech) may or may not be delayed.[7]
In infants with FD, a lack of overflow tears during emotional crying may be noted after the age of 7 months (until this age, overflow emotional tearing may also not occur in unaffected infants;[12] overflow tearing is absent in neonates and begins to appear only after 2–3 months of age[8]).[12]
Affected infants' hands may alternatively appear cool and mottled (from vasoconstriction), or red and swollen (from vasodilation).[8] Red skin blotching is often precipitated by emotional excitement.[8]
In older infants and young children, breath-holding spells may occur, possibly leading to cyanosis or fainting. Breath-holding behaviour usually ceases by age 6.[7]
Breath-holding behaviour usually resolves by age 6. In school-age children, bed wetting, vomiting episodes, impaired pain and temperature perception, impaired blood pressure control (including orthostatic hypotension, a hypertension during periods of psychological excitement or vomiting), learning disabilities (e.g. short attention span; learning disabilities are present in about a third of those with FD, and may require special education), scoliosis, poor bone quality and bone fractures, and kidney and heart issues may be seen.[7]
Adolescence and adulthood
Issues that tend to commence during adolescence or early adulthood include lung damage due to multiple respiratory infections, impaired kidney function, and impaired vision (due to atrophy of the optic nerve).[7] By adulthood, difficulties with balance and unaided walking often arise.[7]
Cause
Familial dysautonomia is the result of mutations in the IKBKAP gene on chromosome 9, which encodes for the IKAP protein (IkB kinase complex-associated protein). Three mutations in IKBKAP have been identified in individuals with FD. The most common FD-causing mutation occurs in intron 20 of the donor gene. Conversion of T→C in intron 20 of the donor gene resulted in shift splicing that generates an IKAP transcript lacking exon 20. Translation of this mRNA results in a truncated protein lacking all of the amino acids encoded by exons 20–37. Another less common mutation is a G→C conversion resulting in a one-amino-acid mutation in 696, where proline substitutes for normal arginine. The decreased amount of functional IKAP protein in cells causes familial dysautonomia.[citation needed]
A clinical diagnosis of FD is supported by a constellation of criteria:[citation needed]
No fungiform papillae on the tongue
Decreased deep-tendon reflexes
Lack of an axon flare following intradermal histamine
No overflow tears with emotional crying
Genetic testing
Genetic testing is performed on a small sample of blood from the tested individual. The DNA is examined with a designed probe specific to the known mutations. The accuracy of the test is above 99%. Dr. Anat Blumenfeld of the Hadassah Medical center in Jerusalem identified chromosome number 9 as the responsible chromosome.[citation needed]
Prenatal testing
Familial dysautonomia is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. If both parents are shown to be carriers by genetic testing, a 25% chance exists that the child will have FD. For pregnancies at increased risk for FD, preimplantation genetic diagnosis or prenatal diagnosis by amniocentesis (at 15–17 weeks) or chorionic villus sampling (at 10–14 weeks) is possible.[citation needed]
Management
No cure for FD has been identified. The only two treatment centers are at New York University Hospital[13] and the Sheba Medical Center in Israel.[14] One is being planned for the San Francisco area.[15] Although the FD-causing gene has been identified and it seems to have tissue-specific expression, no definitive treatment exists at present.[citation needed]
A major issue has been aspiration pneumonia. Fundoplications (by preventing regurgitation) and gastrostomy tubes (to preclude oral nutrition) have reduced the frequency of hospitalization.[citation needed] Other issues that can be treated include FD crises, scoliosis, and various eye conditions due to limited or no tears.[citation needed]
Treatment of FD remains preventative, symptomatic, and supportive. FD does not express itself in a consistent manner. The types and severity of symptoms displayed vary among patients and even at different ages on the same patients, so patients should have specialized individual treatment plans. Medications are used to control vomiting, eye dryness, and abnormal blood pressure. Common management strategies include artificial tears, appropriate feeding strategy (maintenance of adequate nutrition, avoidance of aspiration (thickened formula and differently shaped nipples[further explanation needed] for infants)), daily chest physiotherapy (nebulization, bronchodilators, and postural drainage) for chronic pulmonary disease, pharmaceutical management of autonomic features (e.g. intravenous or rectal diazepam, or rectal chloral hydrate), preventing accidental injury, prevention of orthostatic hypotension (hydration, leg exercise, frequent small meals, a high-salt diet, and medication (e.g. with fludrocortisone)), treatment of orthopedic problems, compensating labile blood pressure.[citation needed]
Parents and patients should be informed regarding daily eye care and early signs of corneal problems, as well as punctal cautery. Informing patients and caretakers has resulted in decreased corneal scarring and need for more aggressive surgical measures such as tarsorrhaphy, conjunctival flaps, and corneal transplants.[citation needed]
Prognosis
Average age of death is in the third decade of life, but affected persons may live into their 70s.[3] Death occurs in 50% of the affected individuals by age 30. The outlook for patients with FD depends on the particular diagnostic category. Patients with chronic, progressive, generalized dysautonomia in the setting of central nervous system degeneration have a generally poor long-term prognosis. Death can occur from pneumonia, acute respiratory failure, or sudden cardiopulmonary arrest in such patients.[citation needed]
The survival rate and quality of life have increased since the mid-1980s, mostly due to a greater understanding of the most dangerous symptoms. At present, FD patients can be expected to function independently if treatment is begun early and if major disabilities are avoided.[citation needed]
Epidemiology
Familial dysautonomia is seen almost exclusively in Ashkenazi Jews and is inherited in an autosomal recessive fashion. Both parents must be carriers for a child to be affected. The carrier frequency in Jews of Eastern and Central European (Ashkenazi) ancestry is about one in 30, while the carrier frequency in non-Jews is unknown. If both parents are carriers, a one in four chance exists with each pregnancy for an affected child. Genetic counseling and genetic testing are recommended for families who may be carriers of familial dysautonomia.[citation needed]
Worldwide, about 600 diagnoses have been recorded since discovery of the disease, with around 350 of them still living.[16]
Research
In January 2001, researchers at Fordham University and Massachusetts General Hospital simultaneously reported finding the genetic mutation that causes FD, a discovery that opens the door to many diagnostic and treatment possibilities.[17][18] Genetic screening subsequently became available in 2001, enabling Ashkenazi Jews to find out if they are carriers.[citation needed]
Stem-cell therapy has been proposed as a potential future treatment. Eventually, treatment could be given in utero.[citation needed]
Research into treatments is being funded by foundations organized and run by parents of those with FD. No governmental support has been given beyond recognizing those diagnosed with FD as eligible for certain programs.[19]
