English: A general CB1 receptor inverse agonist pharmacophore model. Putative CB1 receptor amino acid side chain residues in receptor-ligand interaction are shown. A and B both constitute an aromatic ring connected to a central core unit C. A hydrogen bond acceptor unit D interconnects unit C with a lipophilic
moiety E. Rimonabant is taken as a representative example below. The applied colors
indicate the mutual properties with the general CB1 pharmacophore.
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Dagrun Saevarsdottir
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