Flesh and Bone may refer to:

• Flesh and Bone (film), a 1993 film starring Meg Ryan, Dennis Quaid and James Caan
• Flesh and Bone (miniseries), a 2015 American television series on Starz
• "Flesh and Bone" (Battlestar Galactica), an episode of the 2004 TV series Battlestar Galactica
• Flesh and Bone (Lucy Kaplansky album), 1996
• Flesh and Bone (Richard Marx album), 1997
• "Flesh and Bone", a song by Matt Maher from the album Alive Again
• "Flesh and Bone", a song by The Killers from the album Battle Born
• "Flesh and Bone", a song by Alien Ant Farm from the album ANThology
• "Flesh and Bone", a song by Marion Raven from the album Nevermore
• "Flesh & Bone", a song by Plan B from the album Heaven Before All Hell Breaks Loose
• "Flesh and Bone", a song from the 2020 Disney Channel movie Zombies 2
• Flesh and Bone, a young adult novel by Jonathan Maberry