Flight 191 may refer to:

• Aeroflot Flight 191 (1963), crashed on final approach to Ashgabat International Airport, killing 12 people
• X-15 Flight 191 (1967), or X-15 Flight 3-65-97, experimental test plane, broke apart in flight, killing its test pilot
• Prinair Flight 191 (1972), crashed at Mercedita Airport in Ponce, Puerto Rico, killing five people
• American Airlines Flight 191 (1979), crashed shortly after takeoff from Chicago O'Hare Airport, killing 273
• Delta Air Lines Flight 191 (1985), crashed while on final approach to Dallas-Fort Worth, killing 137
• Comair Flight 191 (2006), crashed on take-off from the wrong runway at Lexington, Kentucky, killing 49; in all ATC communications the call sign was "Comair 191"
• JetBlue Flight 191 (2012), a flight from New York John F. Kennedy airport to Las Vegas, Nevada; diverted to Amarillo, Texas due to erratic pilot behavior