Skeletal formula of fluotracen
Ball-and-stick model of the fluotracen molecule
Clinical data
Routes of
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
  • N,N-dimethyl-3-[10-methyl-2-(trifluoromethyl)-9,10-dihydroanthracen-9-yl]propan-1-amine
CAS Number
PubChem CID
Chemical and physical data
Molar mass347.425 g·mol−1
3D model (JSmol)
  • FC(F)(F)c1ccc3c(c1)C(c2ccccc2C3C)CCCN(C)C

Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity.[1][2][3] This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis.[1] It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder and usual antipsychotics often worsen such symptoms.[1] In any case, however, fluotracen was never marketed.[3]

See also


  1. ^ a b c Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8.
  2. ^ Fowler PJ, Zirkle CL, Macko E, et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung. 27 (8): 1589–95. PMID 410422.
  3. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.